A Cell‐Targeted Non‐Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium‐Containing Cationic Radical Initiator

A cationic fluorescent nanogel thermometer based on thermo‐responsive N‐isopropylacrylamide and environment‐sensitive benzothiadiazole was developed with a new azo compound bearing imidazolium rings as the first cationic radical initiator. This cationic fluorescent nanogel thermometer showed an exce...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-05, Vol.57 (19), p.5413-5417
Main Authors: Uchiyama, Seiichi, Tsuji, Toshikazu, Kawamoto, Kyoko, Okano, Kentaro, Fukatsu, Eiko, Noro, Takahiro, Ikado, Kumiko, Yamada, Sayuri, Shibata, Yuka, Hayashi, Teruyuki, Inada, Noriko, Kato, Masaru, Koizumi, Hideki, Tokuyama, Hidetoshi
Format: Article
Language:English
Subjects:
Cations
Cell proliferation
Cytotoxicity
Fluorescence
fluorescence spectroscopy
fluorescent probes
imaging agents
Isopropylacrylamide
Mammalian cells
nanoparticles
sensors
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A cationic fluorescent nanogel thermometer based on thermo‐responsive N‐isopropylacrylamide and environment‐sensitive benzothiadiazole was developed with a new azo compound bearing imidazolium rings as the first cationic radical initiator. This cationic fluorescent nanogel thermometer showed an excellent ability to enter live mammalian cells in a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C in the range 20–40 °C), and remarkable non‐cytotoxicity, which permitted ordinary cell proliferation and even differentiation of primary cultured cells. A fluorescent nanogel thermometer was prepared with a cationic radical initiator. This thermometer is able to enter live mammalian cells within a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C), and remarkable non‐cytotoxicity, which permitted ordinary cell proliferation and differentiation of primary cultured cells.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201801495