Impact of a triclosan‐containing toothpaste during the progression of experimental peri‐implant mucositis: Clinical parameters and local pattern of osteo‐immunoinflammatory mediators in peri‐implant fluid

Background This study evaluated the influence of a triclosan‐containing toothpaste in the profile of osteo‐immunoinflammatory mediators in peri‐implant crevicular fluid (PICF) and in clinical parameters during progression of peri‐implant mucositis. Methods Twenty‐two clinically healthy patients with...

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Published in:Journal of periodontology (1970) 2018-02, Vol.89 (2), p.203-212
Main Authors: Ribeiro, Fernanda V., Casati, Marcio Z., Casarin, Renato C., Corrêa, Mônica G., Cirano, Fabiano R., Negri, Brenno M., Pimentel, Suzana P.
Format: Article
Language:English
Subjects:
Biomarkers
Cross-Over Studies
cytokines
Dental Implants
Double-Blind Method
Humans
Mucositis
peri‐implantitis
Toothpastes
Triclosan
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Summary:Background This study evaluated the influence of a triclosan‐containing toothpaste in the profile of osteo‐immunoinflammatory mediators in peri‐implant crevicular fluid (PICF) and in clinical parameters during progression of peri‐implant mucositis. Methods Twenty‐two clinically healthy patients with an implant‐supported single‐unit crown were enrolled in this double‐blind, randomized, crossover study carried out in two phases of 21 days each. During an experimental 3‐week period of undisturbed plaque accumulation in the implants, patients were randomly assigned to use three times/day: triclosan (n = 11), triclosan/copolymer/fluoride toothpaste; or placebo (n = 11), fluoride toothpaste. After a professional prophylaxis, a washout period of 30 days was established. Clinical parameters and 15 osteo‐immunoinflammatory mediators in the PICF were evaluated at baseline and at 3, 7, 14, and 21 days. Results Both groups showed increase in plaque index at implant sites from the 3rd until the 21st day (P  0.05), whereas a significant intensification in BOP was observed from the 14th day in the placebo‐treated sites (P 
ISSN:0022-3492
1943-3670
DOI:10.1002/JPER.17-0302