In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytes

Summary As shown by recent research, most of the clinically relevant fungi, including dermatophytes, form biofilms in vitro and in vivo, which may exhibit antimicrobial tolerance that favour recurrent infections. The aim of this study was to determine the minimum inhibitory concentrations (MICs) of...

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Bibliographic Details
Published in:Mycoses 2018-07, Vol.61 (7), p.449-454
Main Authors: Brilhante, Raimunda Sâmia Nogueira, Correia, Edmilson Emanuel Monteiro, Guedes, Glaucia Morgana de Melo, Oliveira, Jonathas Sales, Castelo‐Branco, Débora de Souza Collares Maia, Cordeiro, Rossana de Aguiar, Pinheiro, Adriana de Queiroz, Chaves, Lúcio Jackson Queiroz, Pereira Neto, Waldemiro de Aquino, Sidrim, José Júlio Costa, Rocha, Marcos Fábio Gadelha
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - pharmacology
Arthrodermataceae - drug effects
Arthrodermataceae - growth & development
Azoles - pharmacology
biofilm
Biofilms
Biofilms - drug effects
Biofilms - growth & development
Cat Diseases - microbiology
Cats
Clinical isolates
Colorimetry
Dermatomycoses - microbiology
Dermatomycoses - veterinary
dermatophytes
Dog Diseases - microbiology
Dogs
Fungi
Griseofulvin
Griseofulvin - pharmacology
human isolates
Humans
Itraconazole
Itraconazole - pharmacology
Microbial Sensitivity Tests
Minimum inhibitory concentration
planktonic
susceptibility testing
veterinary isolates
Voriconazole
Voriconazole - pharmacology
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Summary:Summary As shown by recent research, most of the clinically relevant fungi, including dermatophytes, form biofilms in vitro and in vivo, which may exhibit antimicrobial tolerance that favour recurrent infections. The aim of this study was to determine the minimum inhibitory concentrations (MICs) of itraconazole (ITC), voriconazole (VCZ) and griseofulvin (GRI) against Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum in planktonic and biofilm growth. For the planktonic form, susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI), document M38‐A2, while biofilm susceptibility was evaluated using the XTT colorimetric essay. The planktonic growth of all strains was inhibited, with MIC values ranging from 0.00195 to 0.1225 μg/mL for VRC, 0.00195 to 0.25 μg/mL for ITC and
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.12763