A surgical strategy using a fusion image constructed from 11C-methionine PET, 18F-FDG-PET and MRI for glioma with no or minimum contrast enhancement

The objective of this study was to investigate the distribution of 11C-methionine (MET) and F-18 fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) imaging and the hyperintense area in T2 weighted imaging (T2WI) in glioma with no or poor gadolinium enhancement in magnetic resonanc...

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Bibliographic Details
Published in:Journal of neuro-oncology 2018-07, Vol.138 (3), p.537-548
Main Authors: Ideguchi, Makoto, Nishizaki, Takafumi, Ikeda, Norio, Okamura, Tomomi, Tanaka, Yasue, Fujii, Natsumi, Ohno, Machiko, Shimabukuro, Taichi, Kimura, Tokuhiro, Ikeda, Eiji, Suga, Kazuyoshi
Format: Article
Language:English
Subjects:
Clinical Study
Diagnosis
Gadolinium
Glioma
Language
Magnetic resonance imaging
Malignancy
Medical imaging
Medicine
Medicine & Public Health
Methionine
Neurology
NMR
Nuclear magnetic resonance
Oncology
Positron emission tomography
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Summary:The objective of this study was to investigate the distribution of 11C-methionine (MET) and F-18 fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) imaging and the hyperintense area in T2 weighted imaging (T2WI) in glioma with no or poor gadolinium enhancement in magnetic resonance imaging (GdMRI). Cases were also analyzed pathologically. We prospectively investigated 16 patients with non- or minimally enhancing ( 95% in the non-eloquent area in 4/5 cases (80%), whereas 10 of 11 cases (90.9%) had partial resection in the eloquent area. In a case including the language area, 92% resection was achieved based on the MET-uptake area, in contrast to T2WI-based partial resection (65%), because the T2WI+/MET− area defined the language area. Pathological findings showed that the T2WI+/MET+ area is glioma, whereas 6 of 9 T2WI+/MET− lesions included normal tissues. Tissue from T2W1+/MET+/FDG+/GdMRI+ lesions gave an accurate diagnosis of grade in six cases. Non- or minimally enhancing gliomas were classified as having a MET uptake area that totally or partially overlapped with the T2WI hyperintense area. Resection planning with or without a metabolically active area in non- or minimally enhancing gliomas may be useful for accurate diagnosis, malignancy grading, and particularly for eloquent area although further study is needed to analyze the T2WI+/MET− area.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-018-2821-9