Functional status improves in hypertensive older adults: the long-term effects of antihypertensive therapy combined with multicomponent exercise intervention

Background The increasing prevalence of functionally-limited hypertensive individuals highlights the need for interventions to reduce the burden of hypertension-aging-disability and to maximize the chances of healthy aging. Aim This study aims to compare the effects of multicomponent exercise and di...

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Bibliographic Details
Published in:Aging clinical and experimental research 2018-12, Vol.30 (12), p.1483-1495
Main Authors: Baptista, Liliana C., Amorim, André Pinto, Valente-dos-Santos, João, Machado-Rodrigues, Aristides M., Veríssimo, Manuel Teixeira, Martins, Raul A.
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - therapeutic use
Cohort Studies
Exercise
Exercise Therapy
Female
Fitness training programs
Geriatrics/Gerontology
Humans
Hypertension
Hypertension - physiopathology
Hypertension - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Older people
Original Article
Physical Fitness
Quality of Life
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Summary:Background The increasing prevalence of functionally-limited hypertensive individuals highlights the need for interventions to reduce the burden of hypertension-aging-disability and to maximize the chances of healthy aging. Aim This study aims to compare the effects of multicomponent exercise and different pharmacological treatments on functional status and cardiovascular risk outcomes in hypertensive older adults with comorbidities. Methods Participants ( n  = 96) engage in a 3 days/week multicomponent (aerobic + resistance) exercise program and for one of the following three conditions: (1) thiazide-related diuretics (TDs; n  = 33, 69.9 ± 9.5 years); (2) calcium channel blockers (CCBs; n  = 23, 67.0 ± 9.0 years); (3) and β-blockers (βBs; n  = 40, 65.6 ± 7.2 years) medication. Baseline and 2-year follow-up evaluations included the Senior Fitness Test battery, anthropometrics and hemodynamic profile, health-related quality of life (HRQoL; Short-Form Health Survey 36) and health history questionnaires. Results All groups have significantly improved the physical functional status; particularly upper and lower body strength and aerobic endurance and systolic blood pressure. The TDs and βBs groups have diminished the waist circumference and body mass. The CCBs decreased total cholesterol ( P  = 0.028), perceived better physical functioning, physical component score but also augmented bodily pain ( P  
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-018-0925-x