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Molecular enantiorecognition of l‐glucose and d‐glucose in whole blood samples
In the past years, enantioanalysis became very important for clinical analysis; biomarkers/substances of biomedical importance with chiral structure should be analyzed and their presence correlated with the specific disorder. Therefore, we developed a method for the assay of l‐ and d‐glucose, based...
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Published in: | Chirality (New York, N.Y.) N.Y.), 2018-05, Vol.30 (5), p.680-685 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | In the past years, enantioanalysis became very important for clinical analysis; biomarkers/substances of biomedical importance with chiral structure should be analyzed and their presence correlated with the specific disorder. Therefore, we developed a method for the assay of l‐ and d‐glucose, based on molecular recognition of l‐ and d‐glucose. While for d‐glucose there are many methods to assess its quantity, the l‐enantiomer is not routinely detected by standard methods. Two stochastic microsensors based on the immobilization of Copper(II)phthalocyanine and Ni(II)phthalocyanine, in natural diamond powder, were proposed for the enantioanalysis of glucose. The proposed methods proved to have high sensitivities and were able to be used for determination of concentrations as low as 2.5 pg mL−1 for d‐glucose and as low as 2.5 fg mL−1 for l‐glucose. The enatioanalysis was performed with good results in whole blood samples collected from diabetic patients. |
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ISSN: | 0899-0042 1520-636X |
DOI: | 10.1002/chir.22843 |