First report of Candida bracarensis in Mexico: hydrolytic enzymes and antifungal susceptibility pattern

Candida bracarensis is an emerging cryptic species within the Candida glabrata clade. To date, little is known about its epidemiology, virulence, and antifungal susceptibility. This study documents the occurrence of C. bracarensis for the first time in Mexico and focuses on its in vitro production o...

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Bibliographic Details
Published in:Folia microbiologica 2018-07, Vol.63 (4), p.517-523
Main Authors: Treviño-Rangel, Rogelio de J., Espinosa-Pérez, José F., Villanueva-Lozano, Hiram, Montoya, Alexandra M., Andrade, Angel, Bonifaz, Alexandro, González, Gloria M.
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Applied Microbiology
Biomedical and Life Sciences
Candida
Candida - classification
Candida - drug effects
Candida - enzymology
Candida - physiology
Candidiasis, Vulvovaginal - microbiology
Caspofungin
Cryptic species
DNA, Fungal - genetics
DNA, Ribosomal Spacer - genetics
Echinocandins
Environmental Engineering/Biotechnology
Enzymes
Epidemiology
Female
Fungi
Fungicides
Genome, Fungal
Humans
Hydrolases - metabolism
Immunology
Life Sciences
Mexico
Micafungin
Microbial Sensitivity Tests
Microbial Viability - drug effects
Microbiology
Minimum inhibitory concentration
Opportunist infection
Phospholipase
Proteinase
Short Communication
Vagina
Virulence
Yeast
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Summary:Candida bracarensis is an emerging cryptic species within the Candida glabrata clade. To date, little is known about its epidemiology, virulence, and antifungal susceptibility. This study documents the occurrence of C. bracarensis for the first time in Mexico and focuses on its in vitro production of hydrolytic enzymes, as well as antifungal susceptibility to echinocandins. This strain was isolated from a vaginal swab of a female with vulvovaginal candidosis; exhibited a very strong activity of aspartyl proteinase, phospholipase, and hemolysin; and was susceptible to caspofungin, anidulafungin, and micafungin (MIC = 0.031 μg/mL). Data obtained could contribute to the knowledge of the epidemiology and virulence attributes of this yeast as a fungal opportunistic human pathogen.
ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-018-0592-5