Role of Magnesium in Vitamin D Activation and Function

Nutrients usually act in a coordinated manner in the body. Intestinal absorption and subsequent metabolism of a particular nutrient, to a certain extent, is dependent on the availability of other nutrients. Magnesium and vitamin D are 2 essential nutrients that are necessary for the physiologic func...

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Bibliographic Details
Published in:Journal of Osteopathic Medicine (Online) 2018-03, Vol.118 (3), p.181-189
Main Authors: Uwitonze, Anne Marie, Razzaque, Mohammed S.
Format: Article
Language:English
Subjects:
Bones
Dentistry
Enzymes
Health sciences
Homeostasis
Humans
Kinases
magnesium
Magnesium - physiology
Magnesium Deficiency - complications
Medicine
Metabolism
Nutrients
Osteopathic medicine
Vitamin D
Vitamin D - physiology
Vitamin D Deficiency - complications
Vitamin deficiency
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Summary:Nutrients usually act in a coordinated manner in the body. Intestinal absorption and subsequent metabolism of a particular nutrient, to a certain extent, is dependent on the availability of other nutrients. Magnesium and vitamin D are 2 essential nutrients that are necessary for the physiologic functions of various organs. Magnesium assists in the activation of vitamin D, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. Deficiency in either of these nutrients is reported to be associated with various disorders, such as skeletal deformities, cardiovascular diseases, and metabolic syndrome. It is therefore essential to ensure that the recommended amount of magnesium is consumed to obtain the optimal benefits of vitamin D.
ISSN:0098-6151
2702-3648
1945-1997
DOI:10.7556/jaoa.2018.037