YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling

•YBX1 is a transcriptional and translational regulator.•YBX1 cross talks with lncRNAs, MajSAT RNAs, miRNAs and tRFs.•YBX1 is involved in signaling at P granules, stress granules and exosomes.•ncRNAs and organelles add another layer of complexity to YBX1 signaling. YBX1 (Y box binding protein 1) is a...

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Bibliographic Details
Published in:European journal of cell biology 2018-04, Vol.97 (3), p.163-167
Main Authors: Suresh, Padmanaban S., Tsutsumi, Rie, Venkatesh, Thejaswini
Format: Article
Language:English
Subjects:
Animals
Cytoplasmic Granules - metabolism
Exosomes - metabolism
Exososmes
Humans
lncRNAs
P granules
RNA, Untranslated - metabolism
Signal Transduction - physiology
Transcriptome - physiology
tRFs
Y-Box-Binding Protein 1 - metabolism
YBX1
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Summary:•YBX1 is a transcriptional and translational regulator.•YBX1 cross talks with lncRNAs, MajSAT RNAs, miRNAs and tRFs.•YBX1 is involved in signaling at P granules, stress granules and exosomes.•ncRNAs and organelles add another layer of complexity to YBX1 signaling. YBX1 (Y box binding protein 1) is an RNA-/DNA-binding multifunctional protein harboring the classical cold shock protein (CSD) domain, an A/P domain, and a long C-terminal domain with alternating positively and negatively charged amino acids. It is a well-established oncogenic transcriptional factor, and regulates apoptosis, translation, cell proliferation, mRNA splicing, repair, differentiation, and stress response. The non-coding transcriptome has added yet another layer of complexity to the YBX1-mediated master regulation of cellular functions. Interestingly, YBX1 has been shown to localize to cytoplasmic granules such as P granules and stress granules. These granules regulate the non-coding transcriptome profile as well as mRNA translation and degradation. In this review, we discuss the recent findings on YBX1 signaling as mediated by various classes of non-coding RNAs, and on the functions of YBX1 at P granules, stress granules, exosomes, and mitochondria. YBX1 is a well-established target for cancer therapy and understanding its functions at organelles and ncRNA transcriptomes will shed new insights for devising organelle based anti-cancer therapies.
ISSN:0171-9335
1618-1298
DOI:10.1016/j.ejcb.2018.02.003