Improving animal research: PREPARE before you ARRIVE

Despite widespread journal endorsement of reporting guidelines, the poor reproducibility of preclinical research is increasingly under debate. 1 2 3 4 Ritskes-Hoitinga and Wever cite preregistration, systematic reviews, and better reporting as major tools for raising standards of animal research. 5...

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Bibliographic Details
Published in:BMJ (Online) 2018-02, Vol.360, p.k760-k760
Main Authors: Smith, Adrian J, Clutton, R Eddie, Lilley, Elliot, Hansen, Kristine E Aa, Brattelid, Trond
Format: Article
Language:English
Subjects:
Cruelty to animals
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Summary:Despite widespread journal endorsement of reporting guidelines, the poor reproducibility of preclinical research is increasingly under debate. 1 2 3 4 Ritskes-Hoitinga and Wever cite preregistration, systematic reviews, and better reporting as major tools for raising standards of animal research. 5 An elephant in the room has been ignored for too long-better reporting does not improve the quality of an experiment that has already been performed. The guidelines contain, of course, many of the elements in reporting guidelines like ARRIVE. 7 But, importantly, PREPARE emphasises additional matters that can have dramatic effects on the scientific validity of the research, as well as on health and safety and animal welfare.
ISSN:0959-8138
1756-1833
DOI:10.1136/bmj.k760