Genomic characterization and evolution of Tacaiuma orthobunyavirus (Peribunyaviridae family) isolated in Brazil

Tacaiuma virus (TCMV) is antigenically characterized as a member of the Anopheles A complex in the Orthobunyavirus genus, Peribunyaviridae family (Bunyavirales order). Clinically, the TCMV infection is characterized by acute febrile illness with myalgia and arthralgia lasting three to five days. How...

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Published in:Infection, genetics and evolution genetics and evolution, 2018-06, Vol.60, p.71-76
Main Authors: de Melo, Aristides Bezerra, de Souza, William Marciel, Acrani, Gustavo Olszanski, Carvalho, Valéria Lima, Romeiro, Marilia Farignoli, Tolardo, Aline Lavado, da Silva, Sandro Patroca, Cardoso, Jedson Ferreira, de Oliveira Chiang, Jannifer, da Silva Gonçalves Vianez, João Lídio, do Socorro da Silva Azevedo, Raimunda, Figueiredo, Luiz Tadeu Moraes, da Costa Vasconcelos, Pedro Fernando, Nunes, Márcio Roberto Teixeira, de Almeida Medeiros, Daniele Barbosa
Format: Article
Language:English
Subjects:
Animals
Arbovirus
Brazil
Bunyavirales
Bunyaviridae Infections - virology
Cercopithecus aethiops
Evolution, Molecular
Genome, Viral - genetics
Genomic characterization
Humans
Orthobunyavirus
Orthobunyavirus - classification
Orthobunyavirus - genetics
Phylogeny
RNA, Viral - analysis
RNA, Viral - genetics
Tacaiuma orthobunyavirus
Vero Cells
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Description
Summary:Tacaiuma virus (TCMV) is antigenically characterized as a member of the Anopheles A complex in the Orthobunyavirus genus, Peribunyaviridae family (Bunyavirales order). Clinically, the TCMV infection is characterized by acute febrile illness with myalgia and arthralgia lasting three to five days. However, the genomic and evolutionary aspect of this virus has not been elucidated. In this study, we described the complete coding sequences of three segments of two TCMV strains isolated in Brazil and three complete coding sequences of the small segment of three TCMV strains. All the strains sequenced in this study showed the typical genomic organization of orthobunyaviruses that infect vertebrates, except for the absence of the open reading frame that encodes the well-described non-structural small protein. This study presents the genomic and evolutionary characterization of TCMV strains and would be helpful for diagnostic purposes and epidemiology. •First report of complete coding sequence of Tacaiuma orthobunyavirus•Expansion of the orthobunyaviruses diversity•Genomic and phylogenetic characterization of five strains of Tacaiuma orthobunyavirus
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2018.02.027