Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities

[Display omitted] •Polysaccharide isolated from Hericium erinaceus fruiting body exerted gastroprotective activity.•The polysaccharide had antioxidant activities in vitro.•Potentials of the polysaccharide in preventing duodenum ulcer and promoting colonic health of rat were observed.•The mechanism o...

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Bibliographic Details
Published in:Carbohydrate polymers 2018-04, Vol.186, p.100-109
Main Authors: Wang, Xiao-Yin, Yin, Jun-Yi, Zhao, Ming-Ming, Liu, Shi-Yu, Nie, Shao-Ping, Xie, Ming-Yong
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory
Antioxidant activity
Antioxidants - chemistry
Antioxidants - therapeutic use
Dinoprostone - metabolism
Epidermal Growth Factor - metabolism
Ethanol - toxicity
Gastric Mucosa - drug effects
Gastric Mucosa - pathology
Gastroprotective activity
Hericium erinaceus
Interleukin-1beta - metabolism
Nitric Oxide - metabolism
Polysaccharide
Polysaccharides - chemistry
Polysaccharides - therapeutic use
Pylorus - drug effects
Rats
Stomach Ulcer - drug therapy
Tumor Necrosis Factor-alpha - metabolism
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Summary:[Display omitted] •Polysaccharide isolated from Hericium erinaceus fruiting body exerted gastroprotective activity.•The polysaccharide had antioxidant activities in vitro.•Potentials of the polysaccharide in preventing duodenum ulcer and promoting colonic health of rat were observed.•The mechanism of gastroprotective activity might involve its antisecretory, antioxidant, anti-inflammatory and increments of defensive factors. The gastroprotective activity of Hericium erinaceus polysaccharide was investigated in rats. The antioxidant activities were also evaluated. Pre-treatment of polysaccharide could reduce ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer. The polysaccharide exhibited scavenging activities of 1, 1-diphenyl-2-picryl-hydrozyl and hydroxyl radicals, and ferrous ion-chelating ability. In the pylorus ligation-induced model, gastric secretions (volume of gastric juice, gastric acid, pepsin and mucus) of ulcer rats administrated with polysaccharide were regulated. Levels of tumor necrosis factor-α and interleukins-1β in serum, and myeloperoxidase activity of gastric tissue were reduced, while antioxidant status of gastric tissue was improved. Defensive factors (nitric oxide, prostaglandin E2, epidermal growth factor) in gastric tissue were increased. These results indicate that Hericium erinaceus polysaccharide possess gastroprotective activity, and the possible mechanisms are related to its regulations of gastric secretions, improvements of anti-inflammatory and antioxidant status, as well as increments of defensive factors releases.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2018.01.004