The intrapartum and perinatal risks of sleep-disordered breathing in pregnancy: a systematic review and metaanalysis

Sleep-disordered breathing is an increasingly common condition in nonobstetric populations and is associated with significant morbidity. The incidence of sleep-disordered breathing in pregnancy is unknown, and it is likely that many cases go undiagnosed. A systematic review and metaanalysis was unde...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2018-08, Vol.219 (2), p.147-161.e1
Main Authors: Brown, Nicole T., Turner, Jessica M., Kumar, Sailesh
Format: Article
Language:English
Subjects:
Apgar score
birthweight
cesarean delivery
cord pH
metaanalysis
neonatal intensive care unit admission
obstructive sleep apnea
outcome
perinatal death
sleep-disordered breathing
stillbirth
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Summary:Sleep-disordered breathing is an increasingly common condition in nonobstetric populations and is associated with significant morbidity. The incidence of sleep-disordered breathing in pregnancy is unknown, and it is likely that many cases go undiagnosed. A systematic review and metaanalysis was undertaken to determine whether pregnant women who receive a diagnosis of sleep-disordered breathing are more likely to have adverse intrapartum and perinatal outcomes compared with control subjects. PubMed, Embase, and Cinahl databases were searched for full-text publications in English of sleep-disordered breathing and human pregnancy up to June 2017. Only studies that reported on sleep-disordered breathing in relation to gestational age or birthweight at delivery, preterm birth, mode of delivery, cord pH, Apgar score, nursery admission, stillbirth or perinatal death, meconium at delivery, or wound complications were included. A total of 1576 results were identified; 33 studies met inclusion criteria. Women with sleep-disordered breathing were older (mean difference, 1.66; 95% confidence interval, 1.04–2.28) and had a higher body mass index (mean difference, 3.31; 95% confidence interval, 2.30–4.32) than those who did not. Maternal sleep-disordered breathing was associated significantly with preterm birth (
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2018.02.004