Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide–chlorophyll-based photodynamic therapy (PDT) agents with “sandwich” dimeric structure to enhance the PDT effect and active targeting property t...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2018-03, Vol.10 (11), p.9197-9202
Main Authors: Cai, Qian, Fei, Yue, An, Hong-Wei, Zhao, Xiao-Xiao, Ma, Yang, Cong, Yong, Hu, Liming, Li, Li-Li, Wang, Hao
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Intracellular Space
Macrophages
Photochemotherapy
Photosensitizing Agents
Prospective Studies
Staphylococcal Infections
Staphylococcus aureus
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Summary:The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide–chlorophyll-based photodynamic therapy (PDT) agents with “sandwich” dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.7b19056