Amdoparvovirus Infection in Red Pandas (Ailurus fulgens)

Aleutian mink disease virus is the type species in the genus Amdoparvovirus, and in mink and other Mustelidae can cause either subclinical disease or fatal chronic immune stimulation and immune complex disease. The authors describe a novel amdoparvovirus in the endangered red panda (Ailurus fulgens)...

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Bibliographic Details
Published in:Veterinary pathology 2018-07, Vol.55 (4), p.552-561
Main Authors: Alex, Charles E., Kubiski, Steven V., Li, Linlin, Sadeghi, Mohammadreza, Wack, Raymund F., McCarthy, Megan A., Pesavento, Joseph B., Delwart, Eric, Pesavento, Patricia A.
Format: Article
Language:English
Subjects:
Ailuridae - virology
Animals
Endangered Species
Feces - virology
Female
Genetic Variation
Genome, Viral - genetics
In Situ Hybridization - veterinary
Male
Metagenomics
Microscopy, Electron - veterinary
Parvoviridae Infections - diagnostic imaging
Parvoviridae Infections - pathology
Parvoviridae Infections - veterinary
Parvoviridae Infections - virology
Parvovirinae - genetics
Parvovirinae - isolation & purification
Phylogeny
Polymerase Chain Reaction - veterinary
Virus Shedding
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Summary:Aleutian mink disease virus is the type species in the genus Amdoparvovirus, and in mink and other Mustelidae can cause either subclinical disease or fatal chronic immune stimulation and immune complex disease. The authors describe a novel amdoparvovirus in the endangered red panda (Ailurus fulgens), discovered using viral metagenomics. The authors analyzed the prevalence, tissue distribution, and disease association by PCR, in situ hybridization, electron microscopy, and histology in a group of 6 red pandas from a single zoological collection. The study incorporates a fecal shedding survey and analysis of tissues from 4 necropsied animals over a 12-year span. The tentatively named red panda amdoparvovirus (RpAPV) was detected in the feces and/or tissues of all animals tested. At necropsy of 1 geriatric animal, infection was associated with pyogranulomatous peritonitis, pancreatitis, and myocarditis. Other animals had detectable low-level viral nucleic acid in lymph nodes and both oral and intestinal epithelium at the time of necropsy. Full-length genome sequences of RpAPV strains from 2 animals had 12% sequence divergence, demonstrating genetic diversity even among in-contact animals. RpAPV is a persistent infection in this cohort of red pandas, and has variable clinical expression.
ISSN:0300-9858
1544-2217
DOI:10.1177/0300985818758470