N‐terminal B‐type natriuretic peptide (NT‐proBNP) is associated with disease severity in multiple myeloma

Background Elevated levels of cardiovascular markers including N‐terminal B‐type natriuretic peptide (NT‐proBNP) have been shown to be associated with disease severity and mortality in an unselected population of cancer patients without cardiac disease. The aim of this study was to investigate wheth...

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Bibliographic Details
Published in:European journal of clinical investigation 2018-04, Vol.48 (4), p.n/a
Main Authors: Pavo, Noemi, Cho, Anna, Wurm, Raphael, Strunk, Guido, Krauth, Maria, Agis, Hermine, Hülsmann, Martin
Format: Article
Language:English
Subjects:
Cancer
Coronary artery disease
Correlation analysis
Heart diseases
heart failure
inflammation
Light chains
Markers
Mortality
Multiple myeloma
NT‐proBNP
Patients
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Summary:Background Elevated levels of cardiovascular markers including N‐terminal B‐type natriuretic peptide (NT‐proBNP) have been shown to be associated with disease severity and mortality in an unselected population of cancer patients without cardiac disease. The aim of this study was to investigate whether NT‐proBNP levels are related to disease severity in multiple myeloma (MM) and to assess the natural course of NT‐proBNP levels throughout disease progression. Materials and methods We retrospectively analysed a total of 118 patients with MM, who were followed up routinely. NT‐proBNP, beta‐2‐microglobulin (B2M) and levels of plasma cell‐derived light chains were measured at baseline and follow‐up (FUP) visits. All‐cause mortality was defined as primary study endpoint, and the correlation between NT‐proBNP and disease severity reflected by B2M and the International Staging System (ISS) was assessed. Results During a median FUP of 845 (IQR:683‐978) days, 31 patients (26%) died. NT‐proBNP showed a highly significant positive correlation with B2M at first presentation [r = .65, P 
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.12905