Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment

Hepatocellular carcinoma (HCC) commonly arises from a liver damaged by extensive inflammation and fibrosis. Various factors including cytokines, morphogens, and growth factors are involved in the crosstalk between HCC cells and the stromal microenvironment. Increasing our understanding of how stroma...

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Bibliographic Details
Published in:Cancer letters 2018-04, Vol.419, p.175-186
Main Authors: Manka, P., Coombes, J.D., Boosman, R., Gauthier, K., Papa, S., Syn, W.K.
Format: Article
Language:English
Subjects:
Cell growth
Cytokines
Endocrinology
Extracellular matrix
Fibrosis
Gene expression
Growth factors
Hepatocellular carcinoma
Hypothyroidism
Lipids
Liver
Liver cancer
Liver diseases
Liver fibrogenesis
Metabolism
Metabolites
Phenotypes
Rodents
Signal transduction
Stroma
Thyroid
Thyroid gland
Thyroid hormone
Tumor cells
Tumor microenvironment
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Summary:Hepatocellular carcinoma (HCC) commonly arises from a liver damaged by extensive inflammation and fibrosis. Various factors including cytokines, morphogens, and growth factors are involved in the crosstalk between HCC cells and the stromal microenvironment. Increasing our understanding of how stromal components interact with HCC and the signaling pathways involved could help identify new therapeutic and/or chemopreventive targets. It has become increasingly clear that the cross-talk between tumor cells and host stroma plays a key role in modulating tumor growth. Emerging reports suggest a relationship between HCC and thyroid hormone signaling (dysfunction), raising the possibility that perturbed thyroid hormone (TH) regulation influences the cancer microenvironment and cancer phenotype. This review provides an overview of the role of thyroid hormone and its related pathways in HCC and, specifically, its role in regulating the tumor microenvironment. •Perturbations in thyroid hormone regulation are associated with chronic liver diseases.•Thyroid hormone influences cancer microenvironment and cancer phenotype.•Thyroid hormone interacts with known protumorigenic and profibrotic pathways.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2018.01.055