Inhibition of the Replication of Different Strains of Chikungunya Virus by 3‑Aryl-[1,2,3]triazolo[4,5‑d]pyrimidin-7(6H)‑ones

The re-emergence of chikungunya virus (CHIKV) is a serious global health threat. CHIKV is an alphavirus that is transmitted to humans by Aedes mosquitoes; therefore, their wide distribution significantly contributes to the globalization of the disease. Unfortunately, no effective antiviral drugs are...

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Published in:ACS infectious diseases 2018-04, Vol.4 (4), p.605-619
Main Authors: Gómez-SanJuan, Asier, Gamo, Ana-María, Delang, Leen, Pérez-Sánchez, Alfonso, Amrun, Siti Naqiah, Abdelnabi, Rana, Jacobs, Sofie, Priego, Eva-María, Camarasa, María-José, Jochmans, Dirk, Leyssen, Pieter, Ng, Lisa F. P, Querat, Gilles, Neyts, Johan, Pérez-Pérez, María-Jesús
Format: Article
Language:English
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Summary:The re-emergence of chikungunya virus (CHIKV) is a serious global health threat. CHIKV is an alphavirus that is transmitted to humans by Aedes mosquitoes; therefore, their wide distribution significantly contributes to the globalization of the disease. Unfortunately, no effective antiviral drugs are available. We have identified a series of 3-aryl-[1,2,3]­triazolo­[4,5-d]­pyrimidin-7­(6H)-ones as selective inhibitors of CHIKV replication. New series of compounds have now been synthesized with the aim to improve their physicochemical properties and to potentiate the inhibitory activity against different CHIKV strains. Among these newly synthesized compounds modified at position 3 of the aryl ring, tetrahydropyranyl and N-t-butylpiperidine carboxamide derivatives have shown to elicit potent antiviral activity against different clinically relevant CHIKV isolates with 50% effective concentration (EC50) values ranging from 0.30 to 4.5 μM in Vero cells, as well as anti-CHIKV activity in human skin fibroblasts (EC50 = 0.1 μM), a clinically relevant cell system for CHIKV infection.
ISSN:2373-8227
2373-8227
DOI:10.1021/acsinfecdis.7b00219