Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood

BACKGROUND The aim of this study was to evaluate the long-term gonadal sequelae after treatment for childhood Hodgkin’s lymphoma with combination chemotherapy, using up to date fertility parameters and andrological evaluation, including for the first time inhibin B. METHODS There were 56 male patien...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction (Oxford) 2007-12, Vol.22 (12), p.3215-3222
Main Authors: van Beek, Robert D., Smit, Marij, van den Heuvel-Eibrink, Marry M., de Jong, Frank H., Hakvoort-Cammel, Friederike G., van den Bos, Cor, van den Berg, Henk, Weber, Rob F.A., Pieters, Rob, de Muinck Keizer-Schrama, Sabine M.P.F.
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Biological and medical sciences
Biomarkers - blood
Bleomycin - adverse effects
Child
Dacarbazine - adverse effects
Doxorubicin - adverse effects
Epirubicin - adverse effects
Fertility
Follicle Stimulating Hormone - blood
Gynecology. Andrology. Obstetrics
Hodgkin Disease - drug therapy
Hodgkin’s lymphoma
Humans
inhibin B
Inhibins - blood
long-term follow-up
Male
Mechlorethamine - adverse effects
Medical sciences
Prednisone - adverse effects
Procarbazine - adverse effects
Spermatogenesis
Time Factors
Vinblastine - adverse effects
Vincristine - adverse effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND The aim of this study was to evaluate the long-term gonadal sequelae after treatment for childhood Hodgkin’s lymphoma with combination chemotherapy, using up to date fertility parameters and andrological evaluation, including for the first time inhibin B. METHODS There were 56 male patients treated from 1974–1998 for childhood Hodgkin’s lymphoma with combination chemotherapy ABVD or EBVD (adriamycin/epirubicin, bleomycin, vinblastine, dacarbazine) with or without MOPP (mechlorethamine, vincristin, prednisone, procarbazine) with the intention to avoid radiotherapy. These men were studied 15.5 years (range 5.6–30.2 years) after cessation of therapy. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, testosterone, sex hormone-binding globulin (SHBG), sperm concentration and sperm DNA integrity were determined. RESULTS In men treated with MOPP, median FSH and LH were significantly increased (P < 0.001) and inhibin B (17.5 versus 143 ng/l; P < 0.001) and sperm concentration (1.05 versus 49.5 × 106/ml; P < 0.05) were significantly decreased compared with patients treated without MOPP. The number of MOPP courses was significantly correlated with FSH and inhibin B levels. Only inhibin B showed an independent correlation with sperm concentration (r = 0.86; P < 0.001). CONCLUSIONS The use of MOPP chemotherapy causes permanent gonadal damage in the far majority of male survivors of childhood Hodgkin’s lymphoma and inhibin B is the most valuable serum marker for gonadal function.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/dem313