Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for cutaneous melanoma

Susceptibility to solar ultraviolet is an important melanoma risk factor. We investigated the relationship between individual susceptibility to ultraviolet and risk of melanoma by measuring the apoptosis triggered in peripheral lymphocytes by a low-dose ultraviolet B irradiation (50 J/m 2) in young...

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Published in:	European journal of cancer (1990) 2006, Vol.42 (2), p.212-215
Main Authors:	Pedeux, Rémy, Sales, François, Pourchet, Julie, Kallassy, Mireille, Fayolle, Caroline, Boniol, Mathieu, Severi, Gianluca, Ghanem, Ghanem, Nakazawa, Hisayoshi (Nym), Autier, Philippe, Doré, Jean-François
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Aged Apoptosis Apoptosis - radiation effects Biological and medical sciences Case-Control Studies Disease Susceptibility Female Humans Lymphocytes - radiation effects Male Medical sciences Melanoma Melanoma - etiology Melanoma - pathology Middle Aged Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - pathology Peripheral blood lymphocytes Pharmacology. Drug treatments Risk Factors Skin Neoplasms - etiology Skin Neoplasms - pathology Sunlight - adverse effects Tumors Ultraviolet Rays - adverse effects UVB
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Summary:	Susceptibility to solar ultraviolet is an important melanoma risk factor. We investigated the relationship between individual susceptibility to ultraviolet and risk of melanoma by measuring the apoptosis triggered in peripheral lymphocytes by a low-dose ultraviolet B irradiation (50 J/m 2) in young and older melanoma patients and controls. Melanoma patients below the age of 40 are more sensitive to UVB-induced apoptosis than older melanoma patients and healthy controls. Analysis of data (adjusted for age and phototype) shows that UVB-induced apoptosis is an important risk factor for melanoma (OR 9.1, 95% CI [3–28], P = 0.0001). UVB-induced apoptosis is independent of phototype ( P = 0.11, Wald test) and tumour thickness ( P = 0.88, Spearman correlation, for all cases and 0.26 for patients younger than 40 years), and may be used as a functional laboratory test for studying the genetic-environment interactions involved in melanoma occurrence.
ISSN:	0959-8049 1879-0852