Sirolimus-induced regression of a large orbital lymphangioma

Microcystic lymphatic malformations are difficult to treat surgically, especially when located in the orbital apex. Recently, pharmacologic inhibition of the mTOR pathway by sirolimus was reported as a safe and efficacious treatment option for lymphatic malformations (also known as lymphangiomas). W...

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Bibliographic Details
Published in:Orbit (Amsterdam) 2019-02, Vol.38 (1), p.79-80
Main Authors: Lagrèze, Wolf A, Joachimsen, Lutz, Gross, Nikolai, Taschner, Christian, Rössler, Jochen
Format: Article
Language:English
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Summary:Microcystic lymphatic malformations are difficult to treat surgically, especially when located in the orbital apex. Recently, pharmacologic inhibition of the mTOR pathway by sirolimus was reported as a safe and efficacious treatment option for lymphatic malformations (also known as lymphangiomas). We report the case of a young male patient in which a unilateral, retrobulbar lymphatic malformation regressed to a large extent under treatment with 1 mg sirolimus given orally twice a day over a period of six months.
ISSN:0167-6830
1744-5108
DOI:10.1080/01676830.2018.1436569