The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis

OBJECTIVEWith regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-γ), which are important f...

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Bibliographic Details
Published in:Turkish Archives of Otorhinolaryngology 2015-12, Vol.53 (4), p.139-143
Main Authors: Keleş, Erol, Özkara, Şule, İlhan, Nevin, Güngör, Hilal, Karlıdağ, Turgut, Yalçın, Şinasi
Format: Article
Language:English
Subjects:
allergic
cholecalciferol
interferon-gamma
interleukin-10
interleukin-4
rhinitis
th1 cells
th2 cells
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Summary:OBJECTIVEWith regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-γ), which are important for immune response of patients with allergic rhinitis. METHODSThirty adult patients diagnosed with allergic rhinitis (study group) and 40 healthy volunteers (control group) are examined in the research. IFN-γ, IL-4, IL-10, and total immunoglobulin E (IgE) levels from serum samples and vitamin D3 levels from plasma were determined in all patients. RESULTSIn IgE, IL-4, IL-10, IFN-γ, and 1α,25-dihydroxyvitamin D3 levels (p
ISSN:2667-7466
2667-7474
DOI:10.5152/tao.2015.1187