Cardiac Resynchronization Therapy for End-Stage Hypertrophic Cardiomyopathy: The Need for Disease-Specific Criteria

Whether dilated cardiomyopathy (DCM) criteria apply to HCM is unresolved. [...]we aimed to evaluate the effects CRT on symptomatic status and outcome in end-stage HCM in a tertiary referral center. [...]substrate appears hardly amenable to the beneficial effects of CRT. [...]DCM criteria combining s...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2018-01, Vol.71 (4), p.464-466
Main Authors: Cappelli, Francesco, Morini, Sofia, Pieragnoli, Paolo, Targetti, Mattia, Stefàno, Pierluigi, Marchionni, Niccolò, Olivotto, Iacopo
Format: Article
Language:English
Subjects:
Cardiology
Cardiomyopathy
Electrocardiography
Heart diseases
Heart failure
Medical prognosis
Transplants & implants
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Summary:Whether dilated cardiomyopathy (DCM) criteria apply to HCM is unresolved. [...]we aimed to evaluate the effects CRT on symptomatic status and outcome in end-stage HCM in a tertiary referral center. [...]substrate appears hardly amenable to the beneficial effects of CRT. [...]DCM criteria combining systolic dysfunction and LBBB are not applicable to HCM patients. Unfortunately, too few of our patients had cardiac magnetic resonance before CRT (n = 5) to address this important issue. 1 A. Auricchio, G. Baron-Esquivias, P. Bordachar, 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy, Eur Heart J, Vol. 34, 2013, 2281-2329 2 D. Pasqualucci, A. Fornaro, G. Castelli, Clinical spectrum, therapeutic options, and outcome of advanced heart failure in hypertrophic cardiomyopathy, Circ Heart Fail, Vol. 8, 2015, 1014-1021 3 P.S.D. Rogers, A. Marazia, A.W. Chow, Effect of biventricular pacing on symptoms and cardiac remodelling in patients with end-stage hypertrophic cardiomyopathy, Eur J Heart Fail, Vol. 10, 2008, 507-513 4 G. Galati, O. Leone, F. Pasquale, Histological and histometric characterization of myocardial fibrosis in end-stage hypertrophic cardiomyopathy a clinical-pathological study of 30 explanted hearts, Circ Heart Fail, Vol. 9, 2016, e003090 5 I. Olivotto, B.J. Maron, E. Appelbaum, Spectrum and clinical significance of systolic function and myocardial fibrosis assessed by cardiovascular magnetic resonance in hypertrophic cardiomyopathy, Am J Cardiol, Vol. 106, 2010, 261-267
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.11.040