Effects of excessive fibrin deposit and polylactide adhesion barrier on wound healing in thyroidectomy murine wound model

Background We hypothesize that excessive fibrin formation and inflammation induced by antiadhesive material, SurgiWrap (SW), would have an adverse effect on wound healing. It was evaluated by a thyroidectomy murine wound model. Methods Excessive fibrin formation was induced by isthmectomy without he...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2018-06, Vol.40 (6), p.1207-1213
Main Authors: Lim, Yun‐Sung, Kim, Hee‐Bok, Park, Joo Hyun, Cho, Chang Gun, Park, Seok‐Won, Lee, Jae Suk, Kim, Eo Jin, Kwon, Seong Keun
Format: Article
Language:English
Subjects:
Adhesion
Collagen
Fibrin
Head and neck
Hemostasis
Inflammation
Inhibitor drugs
Polylactic acid
Thyroidectomy
tissue adhesions
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background We hypothesize that excessive fibrin formation and inflammation induced by antiadhesive material, SurgiWrap (SW), would have an adverse effect on wound healing. It was evaluated by a thyroidectomy murine wound model. Methods Excessive fibrin formation was induced by isthmectomy without hemostasis. Rats were allocated into isthmectomy with SurgiWrap (I+SW+), I+SW‐, I‐SW+, I‐SW‐, and isthmectomy after electrocautery for hemostasis (I+C+SW‐). The SWs were placed on the superficial and visceral layers for gross and microscopic evaluation. Results Microscopic examination showed collagen deposition occurred in the I‐SW‐ sham group and at a higher level in I+C+SW‐. The collagen deposition decreased in groups without SW with time but increased in groups with SW. Use of SW produced more inflammation and more collagen deposition. The I+SW + group developed the largest area of collagen deposition at 4 weeks and more collagen deposition than the I‐SW + group. Conclusion The SW induced more collagen deposition increasing with time. The collagen deposition produced by SW was worsened by excessive fibrin formation and inflammation.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25096