Risk analysis of malignant potential of oral verrucous hyperplasia: A follow‐up study of 269 patients and copy number variation analysis

Background Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods We calculate the survival rate and prognostic factors...

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Bibliographic Details
Published in:Head & neck 2018-05, Vol.40 (5), p.1046-1056
Main Authors: Wu, Ming‐Heng, Luo, Ji‐Dung, Wang, Wen‐Chang, Chang, Tzu‐Hao, Hwang, Wei‐Lun, Lee, Kuen‐Haur, Liu, Shyun‐Yeu, Yang, Jung‐Wu, Chiou, Chang‐Ta, Chang, Chi‐Hua, Chiang, Wei‐Fan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
betel quid chewer
Cancer
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Chewing
Copy number
copy number variation
DNA Copy Number Variations
Dysplasia
Female
Fibrosis
Follow-Up Studies
Gene amplification
Genetic transformation
Head and neck
Humans
Hyperplasia
Male
malignant transformation
Medical prognosis
Middle Aged
Mouth Neoplasms - genetics
Mouth Neoplasms - pathology
Oral cavity
oral submucous fibrosis
Oral Submucous Fibrosis - genetics
Oral Submucous Fibrosis - pathology
oral verrucous hyperplasia
Prognosis
Risk Assessment
Risk factors
Single-nucleotide polymorphism
Survival
Young Adult
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Summary:Background Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods We calculate the survival rate and prognostic factors using a Kaplan‐Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single‐nucleotide polymorphism (SNP) array. Results The 5‐year disease‐free and cancer‐free survival rates of patients with oral verrucous hyperplasia were approximately 40% and 70%, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of CTTN, FOLR3, ORAOV1, PPFIA1, and RNF121 were associated with the poor prognosis of oral verrucous hyperplasia. Conclusion Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high‐risk factors of patients with oral verrucous hyperplasia. The 5‐copy number variation‐associated genes could be used for early diagnosis and predicting the prognosis.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25076