Treatment of rheumatic diseases in patients with HCV and HIV infection

Abstract A wide variety of rheumatic diseases has been documented in the presence of hepatitis C virus (HCV) infection and in human immunodeficiency virus (HIV) infection. In this conditions, physicians are refrained from using corticosteroids and/or immunosuppressants agents because of the risk of...

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Bibliographic Details
Published in:Autoimmunity reviews 2008-12, Vol.8 (2), p.100-103
Main Authors: Galeazzi, Mauro, Giannitti, Chiara, Manganelli, Stefania, Benucci, Maurizio, Scarpato, Salvatore, Bazzani, Chiara, Caporali, Roberto, Sebastiani, Gian Domenico
Format: Article
Language:English
Subjects:
Allergy and Immunology
Anti-TNF alpha agents
Autoimmune disorders
Cyclosporine A
HCV
Hepatitis C virus
HIV
Human immunodeficiency virus
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Summary:Abstract A wide variety of rheumatic diseases has been documented in the presence of hepatitis C virus (HCV) infection and in human immunodeficiency virus (HIV) infection. In this conditions, physicians are refrained from using corticosteroids and/or immunosuppressants agents because of the risk of favouring viral replication and the progression of the underlying viral disease. In the present review we have focused our attention on the possible role of cyclosporine A (CsA), anti-Tumour Necrosis Factor (TNF) alpha agents in the treatment of HIV or HCV infected autoimmune patients. The results drown from the literature and from our personal experience confirm the safety of CsA and anti-TNF alpha agents, in terms of viral load and liver toxicity. A limited experience also suggest that both therapies can be given in combination in rheumatoid arthritis patients without increasing the risk of adverse events.
ISSN:1568-9972
1568-9972
DOI:10.1016/j.autrev.2008.07.009