Current state and perspectives in hydrogen production by Escherichia coli: roles of hydrogenases in glucose or glycerol metabolism

Escherichia coli has been a robust host strain for much biological research, in particular, research in metabolic engineering, protein engineering, and heterologous gene expression. In this mini review, to understand bacterial hydrogen production by E. coli , the effect of glucose and glycerol metab...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2018-03, Vol.102 (5), p.2041-2050
Main Authors: Maeda, Toshinari, Tran, Kien Trung, Yamasaki, Ryota, Wood, Thomas K.
Format: Article
Language:English
Subjects:
Bacteria
Biological research
Biomedical and Life Sciences
Biotechnology
E coli
Escherichia coli
Gene expression
Glucose
Glucose metabolism
Glycerol
Hydrogen
Hydrogen production
Hydrogenase
Life Sciences
Metabolic engineering
Metabolism
Microbial Genetics and Genomics
Microbiology
Mini-Review
Observations
Physiological aspects
Protein engineering
Reactors
Substrates
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Summary:Escherichia coli has been a robust host strain for much biological research, in particular, research in metabolic engineering, protein engineering, and heterologous gene expression. In this mini review, to understand bacterial hydrogen production by E. coli , the effect of glucose and glycerol metabolism on hydrogen production is compared, and the current approaches to enhance hydrogen production from glycerol as a substrate are reviewed. In addition, the argument from past to present on the functions of E. coli hydrogenases, hydrogenase 1, hydrogenase 2, hydrogenase 3, and hydrogenase 4 is summarized. Furthermore, based on the literature that the E. coli formate-hydrogen lyase is essential for bacterial hydrogen production via recombinant hydrogenases, research achievements from the past regarding heterologous production of hydrogenase are rethought.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-018-8752-8