Sedation of sheep following the administration of acepromazine with buprenorphine or morphine is similar

The aim of this study was to compare sedation of sheep with acepromazine and buprenorphine or morphine. Twenty merino sheep received acepromazine (0.03mg/kg) with buprenorphine (0.02mg/kg, AB, n=10) or morphine (0.3mg/kg, AM, n=10) by intramuscular injection. Sedation was scored (SS) on a scale from...

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Bibliographic Details
Published in:Research in veterinary science 2018-06, Vol.118, p.41-42
Main Authors: Musk, Gabrielle C., Wilkes, Garry J.
Format: Article
Language:English
Subjects:
Acepromazine - administration & dosage
Analgesics
Anesthesia
Animals
Buprenorphine
Buprenorphine - administration & dosage
Confidence intervals
Drugs
Female
Hypnotics and Sedatives - administration & dosage
Injections, Intramuscular - veterinary
Male
Morphine
Morphine - administration & dosage
Narcotics
Opioids
Ovis aries
Premedication
Sheep
Sheep - physiology
Sheep model
Side effects
Veterinary medicine
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Summary:The aim of this study was to compare sedation of sheep with acepromazine and buprenorphine or morphine. Twenty merino sheep received acepromazine (0.03mg/kg) with buprenorphine (0.02mg/kg, AB, n=10) or morphine (0.3mg/kg, AM, n=10) by intramuscular injection. Sedation was scored (SS) on a scale from 0 (no sedation) to 10 (heavy sedation). Response to restraint was scored (RS) on a scale from 0 (agitated) to 4 (relaxed). Three independent blinded observers and a single blinded observer determined the SS and RS, respectively. The SSs were summed (maximum 30). Data were compared using a t-test. Data is mean±SD (95% confidence interval). Each group comprised 2 wethers and 8 ewes. There was no difference between the AB and AM groups: weight 44±3.1kg and 44.7±3kg (p=0.58); SS 4.6±3.2 (2.4–6.9) and 6.6±3.5 (4.1–9.1) (p=0.21); and RS 1.6±1.3 (0.5–2.7) and 2±1.5 (0.7–3.3) (p=0.6). No adverse effects of the drugs were observed. Sedation with AB or AM at these doses is similar in sheep without observed adverse effects. •Sedation with acepromazine and either morphine or buprenorphine is similar in sheep.•Premedication of sheep is an opportunity to provide preventive analgesia in sheep.•Premedication with acepromazine and buprenorphine or morphine provided adequate sedation prior to the induction of anaesthesia.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2018.01.013