Insights into inflammatory priming of mesenchymal stromal cells: functional biological impacts

Mesenchymal stromal cells (MSCs) are multipotent adult cells with relevant biological properties making them interesting tools for cell-based therapy. These cells have the ability to home to sites of injury and secrete bioactive factors as part of their therapeutic functions. However, depending on t...

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Bibliographic Details
Published in:Inflammation research 2018-06, Vol.67 (6), p.467-477
Main Authors: Najar, Mehdi, Krayem, Mohammad, Merimi, Makram, Burny, Arsène, Meuleman, Nathalie, Bron, Dominique, Raicevic, Gordana, Lagneaux, Laurence
Format: Article
Language:English
Subjects:
Allergology
Antigens
Biological properties
Biomedical and Life Sciences
Biomedicine
Cytokines
Dermatology
Empowerment
Genotype & phenotype
Immunology
Immunomodulation
Inflammation
Laboratories
Mesenchymal stem cells
Mesenchyme
Neurology
Pharmacology/Toxicology
Phenotypes
Priming
Review
Rheumatology
Stem cells
Stromal cells
Tumor necrosis factor-TNF
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Summary:Mesenchymal stromal cells (MSCs) are multipotent adult cells with relevant biological properties making them interesting tools for cell-based therapy. These cells have the ability to home to sites of injury and secrete bioactive factors as part of their therapeutic functions. However, depending on the local environment, diverse functions of MSCs can be modulated and thus can influence their therapeutic value. The specific cytokine milieu within the site of inflammation is vital in determining the fate and cell behaviors of MSCs. Indeed, inflammatory signals (called as inflammatory priming), may induce critical changes on the phenotype, multilineage potential, hematopoietic support and immunomodulatory capacity of MSCs. Thus, for appropriate clinical application of MSCs, it is important to well know and understand these effects. In summary, investigating MSC interactions with the inflammatory environment is necessary to empower the therapeutic value of MSCs.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-018-1131-1