Preeclampsia and scleroderma: a prospective nationwide analysis

Introduction. In a preliminary case‐control study, women with scleroderma more frequently reported having had hypertensive complications during pregnancy compared with healthy women. Material and methods. To prospectively investigate this possible association, we conducted a nation‐wide cohort analy...

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Bibliographic Details
Published in:Acta obstetricia et gynecologica Scandinavica 2018-05, Vol.97 (5), p.587-590
Main Authors: Kamper‐Jørgensen, Mads, Gammill, Hilary S., Nelson, J. Lee
Format: Article
Language:English
Subjects:
Adult
Denmark
Epidemiology
Female
Follow-Up Studies
Humans
Hypertension
Pre-Eclampsia
Preeclampsia
Pregnancy
Prospective Studies
Registries
Risk Factors
Scleroderma
Scleroderma, Systemic - etiology
Systemic sclerosis
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Summary:Introduction. In a preliminary case‐control study, women with scleroderma more frequently reported having had hypertensive complications during pregnancy compared with healthy women. Material and methods. To prospectively investigate this possible association, we conducted a nation‐wide cohort analysis of a major hypertensive complication during pregnancy, namely preeclampsia, and later scleroderma. Analyses were based on Danish register‐based birth and hospital contact data on preeclampsia and scleroderma. We followed 778,758 women from time of giving birth between 1978 and 2010 to end of follow‐up, emigration, death, or scleroderma diagnosis, whichever occurred first. The association was evaluated by incidence rate ratios, obtained in Poisson regression models. Results. We report that preeclampsia is associated with a 69% significantly increased risk of later developing scleroderma. Conclusions. Though these findings do not impact clinical care directly, the association of preeclampsia with scleroderma underscores the significant relation of preeclampsia and other adverse pregnancy outcomes with later disease in women and should be included in patient counseling and education.
ISSN:0001-6349
1600-0412
DOI:10.1111/aogs.13296