Highly chemoselective intermolecular cross-benzoin reactions using an ad hoc designed novel N-heterocyclic carbene catalyst

The design of a novel N-heterocyclic carbene catalyst incorporating a bulky yet highly electron-deficient N-aryl substituent has allowed the development of an efficient protocol for the first highly chemoselective intermolecular benzoin condensations between two non-identical aromatic aldehydes.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2018, Vol.16 (5), p.780-786
Main Authors: Delany, Eoghan G, Connon, Stephen J
Format: Article
Language:English
Subjects:
Aldehydes
Aromatic compounds
Benzoin
Catalysis
Catalysts
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Summary:The design of a novel N-heterocyclic carbene catalyst incorporating a bulky yet highly electron-deficient N-aryl substituent has allowed the development of an efficient protocol for the first highly chemoselective intermolecular benzoin condensations between two non-identical aromatic aldehydes.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob03005c