Serum amyloid A level correlated with endoscopic findings in patients with Crohn’s disease—Possible biomarker for evaluating mucosal healing

Mucosal healing (MH) has been proposed as an essential therapeutic goal for treatment of Crohn’s disease (CD) patients. The utility of serum amyloid A (SAA) for prediction of MH in CD patients is lacking. This study was conducted to evaluate the correlation of SAA with CD-related endoscopic disease...

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Bibliographic Details
Published in:Digestive and liver disease 2018-06, Vol.50 (6), p.553-558
Main Authors: Ishihara, Shunji, Tada, Yasumasa, Kawashima, Kousaku, Kataoka, Masatoshi, Sonoyama, Hiroki, Yamashita, Noritsugu, Oka, Akihiko, Kusunoki, Ryusaku, Fukuba, Nobuhiko, Mishima, Yoshiyuki, Oshima, Naoki, Moriyama, Ichiro, Yuki, Takafumi, Kinoshita, Yoshikazu
Format: Article
Language:English
Subjects:
Biomarker
Crohn’s disease
Endoscopy
Mucosal healing
Serum amyloid A
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Summary:Mucosal healing (MH) has been proposed as an essential therapeutic goal for treatment of Crohn’s disease (CD) patients. The utility of serum amyloid A (SAA) for prediction of MH in CD patients is lacking. This study was conducted to evaluate the correlation of SAA with CD-related endoscopic disease activity. SAA levels in serum samples obtained from CD patients as well as endoscopic findings based on a simple endoscopic score for CD (SES-CD) were assessed in relation to CD activity index (CDAI). The diagnostic ability of MH in correlation with SAA level was evaluated using receiver operating characteristic (ROC) curve analysis. Fifty-five patients with CD were enrolled. Mean SAA level was significantly higher in clinical and endoscopic active phases as compared to an inactive phase. SAA level was also significantly correlated with SES-CD (r = 0.64, p 
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2017.12.010