Loading…
Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology
Abstract Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports h...
Saved in:
Published in: | Autoimmunity reviews 2008-12, Vol.8 (2), p.112-115 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c446t-c23406a2dbf05181457fec58be575453f785119459cb35a8a7ddfe1378103bb23 |
---|---|
cites | cdi_FETCH-LOGICAL-c446t-c23406a2dbf05181457fec58be575453f785119459cb35a8a7ddfe1378103bb23 |
container_end_page | 115 |
container_issue | 2 |
container_start_page | 112 |
container_title | Autoimmunity reviews |
container_volume | 8 |
creator | Tozzoli, R Barzilai, O Ram, M Villalta, D Bizzaro, N Sherer, Y Shoenfeld, Y |
description | Abstract Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports have provided conflicting and inconclusive results. Using a new automated multiplex array platform for the detection of antibodies, we determined seroreactivity against Toxoplasma gondii , Treponema pallidum , rubella virus, cytomegalovirus, and Epstein–Barr virus in a large group of Italian AITD patients and healthy controls. Only IgG concentrations against T. gondii were significantly higher in AITD patients than in controls, suggesting that these protozoa may be involved in the initiation of both Hashimoto's thyroiditis and Graves' disease. |
doi_str_mv | 10.1016/j.autrev.2008.07.013 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19882388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1568997208001250</els_id><sourcerecordid>19882388</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-c23406a2dbf05181457fec58be575453f785119459cb35a8a7ddfe1378103bb23</originalsourceid><addsrcrecordid>eNqVkU1v1DAQhiNEJUrhH3DwidsGf8QbhwMSqvioVKmVCmfLsSe7szj2Yjul--_xKhy49uQ5zPNq_LxN847RllG2_XBozVISPLacUtXSvqVMvGgumdyqzTD0_OV_86vmdc4HWrGBD5fN002YwBaMIRMTHKlBEed5CUDK_pQiOuIwg8mQP5J7k4z34ImDskIkThUrOEaHUBN2BkMu5GjKPu6gZv7BsifHFAvEGS2p2D5EH3enN83FZHyGt__eq-bn1y8_rr9vbu--3Vx_vt3YrtuWjeWio1vD3ThRyRTrZF_vlWoE2ctOiqlXkrGhk4MdhTTK9M5NwESvGBXjyMVV837NrUf8XiAXPWO24L0JEJes2aAUF0rVxW5dtCnmnGDSx4SzSSfNqD5r1ge9atZnzZr2umqu2KcVg_qJR4Sks0UIFhym6ki7iM8NsB4DWuN_wQnyIS4pVEGa6cw11Q_nJs9FUlVL5JKKv06FoCo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19882388</pqid></control><display><type>article</type><title>Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology</title><source>ScienceDirect Freedom Collection</source><creator>Tozzoli, R ; Barzilai, O ; Ram, M ; Villalta, D ; Bizzaro, N ; Sherer, Y ; Shoenfeld, Y</creator><creatorcontrib>Tozzoli, R ; Barzilai, O ; Ram, M ; Villalta, D ; Bizzaro, N ; Sherer, Y ; Shoenfeld, Y</creatorcontrib><description>Abstract Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports have provided conflicting and inconclusive results. Using a new automated multiplex array platform for the detection of antibodies, we determined seroreactivity against Toxoplasma gondii , Treponema pallidum , rubella virus, cytomegalovirus, and Epstein–Barr virus in a large group of Italian AITD patients and healthy controls. Only IgG concentrations against T. gondii were significantly higher in AITD patients than in controls, suggesting that these protozoa may be involved in the initiation of both Hashimoto's thyroiditis and Graves' disease.</description><identifier>ISSN: 1568-9972</identifier><identifier>EISSN: 1568-9972</identifier><identifier>DOI: 10.1016/j.autrev.2008.07.013</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Allergy and Immunology ; Autoimmune thyroid diseases ; Cytomegalovirus ; Epstein-Barr virus ; Infections ; Proteomic technology ; Rubella virus ; Toxoplasma gondii ; Treponema pallidum</subject><ispartof>Autoimmunity reviews, 2008-12, Vol.8 (2), p.112-115</ispartof><rights>Elsevier B.V.</rights><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-c23406a2dbf05181457fec58be575453f785119459cb35a8a7ddfe1378103bb23</citedby><cites>FETCH-LOGICAL-c446t-c23406a2dbf05181457fec58be575453f785119459cb35a8a7ddfe1378103bb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Tozzoli, R</creatorcontrib><creatorcontrib>Barzilai, O</creatorcontrib><creatorcontrib>Ram, M</creatorcontrib><creatorcontrib>Villalta, D</creatorcontrib><creatorcontrib>Bizzaro, N</creatorcontrib><creatorcontrib>Sherer, Y</creatorcontrib><creatorcontrib>Shoenfeld, Y</creatorcontrib><title>Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology</title><title>Autoimmunity reviews</title><description>Abstract Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports have provided conflicting and inconclusive results. Using a new automated multiplex array platform for the detection of antibodies, we determined seroreactivity against Toxoplasma gondii , Treponema pallidum , rubella virus, cytomegalovirus, and Epstein–Barr virus in a large group of Italian AITD patients and healthy controls. Only IgG concentrations against T. gondii were significantly higher in AITD patients than in controls, suggesting that these protozoa may be involved in the initiation of both Hashimoto's thyroiditis and Graves' disease.</description><subject>Allergy and Immunology</subject><subject>Autoimmune thyroid diseases</subject><subject>Cytomegalovirus</subject><subject>Epstein-Barr virus</subject><subject>Infections</subject><subject>Proteomic technology</subject><subject>Rubella virus</subject><subject>Toxoplasma gondii</subject><subject>Treponema pallidum</subject><issn>1568-9972</issn><issn>1568-9972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqVkU1v1DAQhiNEJUrhH3DwidsGf8QbhwMSqvioVKmVCmfLsSe7szj2Yjul--_xKhy49uQ5zPNq_LxN847RllG2_XBozVISPLacUtXSvqVMvGgumdyqzTD0_OV_86vmdc4HWrGBD5fN002YwBaMIRMTHKlBEed5CUDK_pQiOuIwg8mQP5J7k4z34ImDskIkThUrOEaHUBN2BkMu5GjKPu6gZv7BsifHFAvEGS2p2D5EH3enN83FZHyGt__eq-bn1y8_rr9vbu--3Vx_vt3YrtuWjeWio1vD3ThRyRTrZF_vlWoE2ctOiqlXkrGhk4MdhTTK9M5NwESvGBXjyMVV837NrUf8XiAXPWO24L0JEJes2aAUF0rVxW5dtCnmnGDSx4SzSSfNqD5r1ge9atZnzZr2umqu2KcVg_qJR4Sks0UIFhym6ki7iM8NsB4DWuN_wQnyIS4pVEGa6cw11Q_nJs9FUlVL5JKKv06FoCo</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Tozzoli, R</creator><creator>Barzilai, O</creator><creator>Ram, M</creator><creator>Villalta, D</creator><creator>Bizzaro, N</creator><creator>Sherer, Y</creator><creator>Shoenfeld, Y</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>20081201</creationdate><title>Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology</title><author>Tozzoli, R ; Barzilai, O ; Ram, M ; Villalta, D ; Bizzaro, N ; Sherer, Y ; Shoenfeld, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-c23406a2dbf05181457fec58be575453f785119459cb35a8a7ddfe1378103bb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Allergy and Immunology</topic><topic>Autoimmune thyroid diseases</topic><topic>Cytomegalovirus</topic><topic>Epstein-Barr virus</topic><topic>Infections</topic><topic>Proteomic technology</topic><topic>Rubella virus</topic><topic>Toxoplasma gondii</topic><topic>Treponema pallidum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tozzoli, R</creatorcontrib><creatorcontrib>Barzilai, O</creatorcontrib><creatorcontrib>Ram, M</creatorcontrib><creatorcontrib>Villalta, D</creatorcontrib><creatorcontrib>Bizzaro, N</creatorcontrib><creatorcontrib>Sherer, Y</creatorcontrib><creatorcontrib>Shoenfeld, Y</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Autoimmunity reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tozzoli, R</au><au>Barzilai, O</au><au>Ram, M</au><au>Villalta, D</au><au>Bizzaro, N</au><au>Sherer, Y</au><au>Shoenfeld, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology</atitle><jtitle>Autoimmunity reviews</jtitle><date>2008-12-01</date><risdate>2008</risdate><volume>8</volume><issue>2</issue><spage>112</spage><epage>115</epage><pages>112-115</pages><issn>1568-9972</issn><eissn>1568-9972</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>Abstract Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports have provided conflicting and inconclusive results. Using a new automated multiplex array platform for the detection of antibodies, we determined seroreactivity against Toxoplasma gondii , Treponema pallidum , rubella virus, cytomegalovirus, and Epstein–Barr virus in a large group of Italian AITD patients and healthy controls. Only IgG concentrations against T. gondii were significantly higher in AITD patients than in controls, suggesting that these protozoa may be involved in the initiation of both Hashimoto's thyroiditis and Graves' disease.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.autrev.2008.07.013</doi><tpages>4</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1568-9972 |
ispartof | Autoimmunity reviews, 2008-12, Vol.8 (2), p.112-115 |
issn | 1568-9972 1568-9972 |
language | eng |
recordid | cdi_proquest_miscellaneous_19882388 |
source | ScienceDirect Freedom Collection |
subjects | Allergy and Immunology Autoimmune thyroid diseases Cytomegalovirus Epstein-Barr virus Infections Proteomic technology Rubella virus Toxoplasma gondii Treponema pallidum |
title | Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T05%3A38%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Infections%20and%20autoimmune%20thyroid%20diseases:%20Parallel%20detection%20of%20antibodies%20against%20pathogens%20with%20proteomic%20technology&rft.jtitle=Autoimmunity%20reviews&rft.au=Tozzoli,%20R&rft.date=2008-12-01&rft.volume=8&rft.issue=2&rft.spage=112&rft.epage=115&rft.pages=112-115&rft.issn=1568-9972&rft.eissn=1568-9972&rft_id=info:doi/10.1016/j.autrev.2008.07.013&rft_dat=%3Cproquest_cross%3E19882388%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c446t-c23406a2dbf05181457fec58be575453f785119459cb35a8a7ddfe1378103bb23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=19882388&rft_id=info:pmid/&rfr_iscdi=true |