Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology

Abstract Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports h...

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Bibliographic Details
Published in:Autoimmunity reviews 2008-12, Vol.8 (2), p.112-115
Main Authors: Tozzoli, R, Barzilai, O, Ram, M, Villalta, D, Bizzaro, N, Sherer, Y, Shoenfeld, Y
Format: Article
Language:English
Subjects:
Allergy and Immunology
Autoimmune thyroid diseases
Cytomegalovirus
Epstein-Barr virus
Infections
Proteomic technology
Rubella virus
Toxoplasma gondii
Treponema pallidum
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Summary:Abstract Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports have provided conflicting and inconclusive results. Using a new automated multiplex array platform for the detection of antibodies, we determined seroreactivity against Toxoplasma gondii , Treponema pallidum , rubella virus, cytomegalovirus, and Epstein–Barr virus in a large group of Italian AITD patients and healthy controls. Only IgG concentrations against T. gondii were significantly higher in AITD patients than in controls, suggesting that these protozoa may be involved in the initiation of both Hashimoto's thyroiditis and Graves' disease.
ISSN:1568-9972
1568-9972
DOI:10.1016/j.autrev.2008.07.013