Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register

The objective of this study is to assess (1) the concordance and validity of schizophrenia register diagnoses among children and adolescents (early onset schizophrenia = EOS) in the Danish Psychiatric Central Research Register (DPCRR), and (2) the validity of clinical record schizophrenia diagnoses....

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Bibliographic Details
Published in:European child & adolescent psychiatry 2018-08, Vol.27 (8), p.965-975
Main Authors: Vernal, Ditte Lammers, Stenstrøm, Anne Dorte, Staal, Nina, Christensen, Anne Marie Raabjerg, Ebbesen, Christine, Pagsberg, Anne Katrine, Correll, Christoph U., Nielsen, René Ernst, Lauritsen, Marlene Briciet
Format: Article
Language:English
Subjects:
Adolescents
Age of onset
Child & adolescent psychiatry
Child and Adolescent Psychiatry
Children
Classification
Diagnosis
Hospitalization
Interrater reliability
Kappa coefficient
Males
Medical diagnosis
Medicine
Medicine & Public Health
Men
Mental disorders
Original Contribution
Psychiatric records
Psychiatry
Registration
Schizophrenia
Validation studies
Validity
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Summary:The objective of this study is to assess (1) the concordance and validity of schizophrenia register diagnoses among children and adolescents (early onset schizophrenia = EOS) in the Danish Psychiatric Central Research Register (DPCRR), and (2) the validity of clinical record schizophrenia diagnoses. Psychiatric records from 200 patients with a first-time diagnosis of schizophrenia (F20.x) at age  0.78–0.83 depending on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS.
ISSN:1018-8827
1435-165X
DOI:10.1007/s00787-017-1102-z