Contribution of photodynamic therapy in wound healing: A systematic review

We researched articles that used photodynamic therapy (PDT) for skin wound healing in humans. The systematic review was conducted through scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS. T...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2018-03, Vol.21, p.294-305
Main Authors: Nesi-Reis, Vanessa, Lera-Nonose, Daniele Stéfanie Sara Lopes, Oyama, Jully, Silva-Lalucci, Marielle Priscila Paula, Demarchi, Izabel Galhardo, Aristides, Sandra Mara Alessi, Teixeira, Jorge Juarez Vieira, Silveira, Thaís Gomes Verzignassi, Lonardoni, Maria Valdrinez Campana
Format: Article
Language:English
Subjects:
Cell Death - radiation effects
Collagen - biosynthesis
Elastin - biosynthesis
Fibroblasts - metabolism
Humans
Metalloproteases - biosynthesis
Photochemistry
Photochemotherapy
Photochemotherapy - adverse effects
Photochemotherapy - instrumentation
Photochemotherapy - methods
Photosensitizing agents
Photosensitizing Agents - therapeutic use
Re-epithelialization
Regeneration
Skin Neoplasms - radiotherapy
Skin Ulcer - radiotherapy
Transforming Growth Factors - biosynthesis
Wound healing
Wound Healing - radiation effects
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Summary:We researched articles that used photodynamic therapy (PDT) for skin wound healing in humans. The systematic review was conducted through scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS. The main types of wound described in selected articles in this review were chronic ulcer and non-melanoma skin cancer. For accomplishing the PDT, second generation of photosensitizing agents with laser or light emitting diode were used. The studies demonstrated that PDT contribute in several ways to the wound healing process: leading to cellular death; reducing or increasing inflammation; stimulating fibroblasts proliferation and, consequently, of collagen and elastin; raising transforming growth factor beta and metalloproteinases. Based on this, PDT provided good results in wound healing process, acting in several steps and accelerating tissue repair. PDT improved healing in many wound models in humans, revealing itself as a promising therapeutic modality for stimulating wound healing and remodelling.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2017.12.015