Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology

Background Diabetes and periodontitis are chronic non‐communicable diseases independently associated with mortality and have a bidirectional relationship. Aims To update the evidence for their epidemiological and mechanistic associations and re‐examine the impact of effective periodontal therapy upo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical periodontology 2018-02, Vol.45 (2), p.138-149
Main Authors: Sanz, Mariano, Ceriello, Antonio, Buysschaert, Martin, Chapple, Iain, Demmer, Ryan T., Graziani, Filippo, Herrera, David, Jepsen, Søren, Lione, Luca, Madianos, Phoebus, Mathur, Manu, Montanya, Eduard, Shapira, Lior, Tonetti, Maurizio, Vegh, Daniel
Format: Article
Language:English
Subjects:
association
chronic kidney disease
complications
Dentistry
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Epidemiology
gestational diabetes
Glucose
Gum disease
HbA1c
Hemoglobin
incident
Insulin
Interleukin 1
Interleukin 6
intervention
mechanisms
mortality
nephropathy
NF-κB protein
Osteoprotegerin
Oxidative stress
periodontal disease
Periodontal diseases
Periodontitis
retinopathy
Toll-like receptors
Tumor necrosis factor
Tumors
type 1 diabetes
type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Diabetes and periodontitis are chronic non‐communicable diseases independently associated with mortality and have a bidirectional relationship. Aims To update the evidence for their epidemiological and mechanistic associations and re‐examine the impact of effective periodontal therapy upon metabolic control (glycated haemoglobin, HbA1C). Epidemiology There is strong evidence that people with periodontitis have elevated risk for dysglycaemia and insulin resistance. Cohort studies among people with diabetes demonstrate significantly higher HbA1C levels in patients with periodontitis (versus periodontally healthy patients), but there are insufficient data among people with type 1 diabetes. Periodontitis is also associated with an increased risk of incident type 2 diabetes. Mechanisms Mechanistic links between periodontitis and diabetes involve elevations in interleukin (IL)‐1‐β, tumour necrosis factor‐α, IL‐6, receptor activator of nuclear factor‐kappa B ligand/osteoprotegerin ratio, oxidative stress and Toll‐like receptor (TLR) 2/4 expression. Interventions Periodontal therapy is safe and effective in people with diabetes, and it is associated with reductions in HbA1C of 0.27–0.48% after 3 months, although studies involving longer‐term follow‐up are inconclusive. Conclusions The European Federation of Periodontology (EFP) and the International Diabetes Federation (IDF) report consensus guidelines for physicians, oral healthcare professionals and patients to improve early diagnosis, prevention and comanagement of diabetes and periodontitis.
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.12808