Retroperitoneal ectopic brain: Case report and literature review

Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine‐need...

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Bibliographic Details
Published in:Diagnostic cytopathology 2018-06, Vol.46 (6), p.528-531
Main Authors: Díaz del Arco, Cristina, Ortega Medina, Luis, Subhi‐Issa Ahmad, Issa
Format: Article
Language:English
Subjects:
Biomarkers - metabolism
Biopsy, Fine-Needle
Brain
Case reports
Cellular biology
Choristoma - diagnostic imaging
Choristoma - pathology
Cytology
Cytoplasm
ectopic brain
ectopic neural tissue
Ependymal cells
fine‐needle aspiration cytology
Gestation
Glial cells
Glial fibrillary acidic protein
glial heterotopia
Histology
Humans
Infant, Extremely Premature
Infant, Newborn
Literature reviews
Male
Neuronal-glial interactions
Nuclei (cytology)
Peritoneal Diseases - diagnostic imaging
Peritoneal Diseases - pathology
Retroperitoneal Space - diagnostic imaging
Retroperitoneal Space - pathology
Retroperitoneum
Synaptophysin
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Summary:Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine‐needle aspiration (FNA) cytology and subsequent resection. Our patient was a male infant born at 26 weeks’ gestation. A retroperitoneal solid‐cystic lesion measuring 3.8 cm was identified by abdominal ultrasound. FNA was performed and cytology showed highly cellular smears with single cells and masses of fibrillary material. Cells were small with rounded irregular nuclei and variable cytoplasm. Multinucleated cells, cells with neuronal morphology, calcifications, and hemosiderophages could also be seen. The lesion was excised and histology showed fibrillary areas, glial cells, neurons, and ependymal cells. Synaptophysin, GFAP, and EMA were expressed in distinct areas and cell types. No recurrences were observed.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23882