Capsaicin prevents ethanol-induced teratogenicity in cultured mouse whole embryos

Prenatal exposure to alcohol promotes the level of reactive oxygen species within embryos and results in developmental disorders. In this study, we investigated the effect of capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient in red peppers, on ethanol-induced teratogen...

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Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2008-11, Vol.26 (3), p.292-297
Main Authors: Kim, Mi-Ra, Lee, Ki-Nam, Yon, Jung-Min, Lee, Se-Ra, Jin, Yan, Baek, In-Jeoung, Lee, Beom Jun, Yun, Young Won, Nam, Sang-Yoon
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - prevention & control
Alcoholism and acute alcohol poisoning
Animals
Antioxidant
Antioxidants - pharmacology
Biological and medical sciences
Capsaicin
Capsaicin - pharmacology
Embryology: invertebrates and vertebrates. Teratology
Ethanol
Ethanol - toxicity
Female
Fundamental and applied biological sciences. Psychology
Glutathione peroxidase
Glutathione Peroxidase - genetics
Medical sciences
Mice
Mice, Inbred ICR
Organ Culture Techniques
RNA, Messenger - analysis
Superoxide dismutase
Teratogenicity
Teratology. Teratogens
Toxicology
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Summary:Prenatal exposure to alcohol promotes the level of reactive oxygen species within embryos and results in developmental disorders. In this study, we investigated the effect of capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient in red peppers, on ethanol-induced teratogenicity in mouse embryos (embryonic days 8.5–10.5). In response to ethanol administration (1.0 μl/ml), developmental parameters such as yolk sac circulation, allantois, heart, hindbrain, midbrain, forebrain, otic and optic systems, branchial bar, olfactory system, forelimb, hindlimb, and somites decreased significantly in comparison with those of control group ( p < 0.05). However, the concurrent administration of capsaicin (1 × 10 −8 μg/ml or 1 × 10 −7 μg/ml) and ethanol significantly ameliorated most of the morphological scores excepting yolk sac circulation and hindlimb scores ( p < 0.05). Furthermore, the levels of superoxide dismutase activity and cytoplasmic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNAs in the ethanol-treated embryos recovered to the levels observed in control embryos by capsaicin co-administration. These results indicate that capsaicin has a protective effect against ethanol-induced teratogenicity via an antioxidative activity.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2008.09.006