Serum substance P: an indicator of disease activity and subclinical inflammation in rheumatoid arthritis

The aim of the is study is to examine the role of serum substance P (SP) levels as a simple biomarker for rheumatoid arthritis (RA) disease activity, its correlation with other markers of disease activity, and with selected clinical parameters. The study comprised 90 RA patients and 24 healthy contr...

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Bibliographic Details
Published in:Clinical rheumatology 2018-04, Vol.37 (4), p.901-908
Main Authors: Barbosa-Cobos, Rosa Elda, Lugo-Zamudio, Gustavo, Flores-Estrada, Javier, Becerril-Mendoza, Lizbeth Teresa, Rodríguez-Henríquez, Pedro, Torres-González, Rubén, Moreno-Eutimio, Mario Adán, Ramirez-Bello, Julian, Moreno, José
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - diagnosis
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Correlation analysis
Doppler effect
Enzyme-linked immunosorbent assay
Female
Health risk assessment
Humans
Inflammation - blood
Inflammation - diagnosis
Joint diseases
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Remission
Rheumatoid arthritis
Rheumatology
Severity of Illness Index
Statistical analysis
Substance P
Substance P - blood
Ultrasonic imaging
Ultrasonography
Ultrasound
Young Adult
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Summary:The aim of the is study is to examine the role of serum substance P (SP) levels as a simple biomarker for rheumatoid arthritis (RA) disease activity, its correlation with other markers of disease activity, and with selected clinical parameters. The study comprised 90 RA patients and 24 healthy controls. RA activity was assessed by means of the disease activity 28-C-reactive protein (DAS28-CRP) index and ultrasound power Doppler (USPD) by the German ultrasound score based on seven joints. SP serum values were obtained by means of an ELISA commercial kit. Statistics were achieved by the Student’s t test and Spearman correlation analysis with Bonferroni correction. As a group, RA patients had significantly increased levels of SP compared with healthy controls ( p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-017-3929-6