Application of ω‑Transaminases in the Pharmaceutical Industry

Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential “green alternative” to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω...

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Bibliographic Details
Published in:Chemical reviews 2018-01, Vol.118 (1), p.349-367
Main Authors: Kelly, Stephen A, Pohle, Stefan, Wharry, Scott, Mix, Stefan, Allen, Christopher C.R, Moody, Thomas S, Gilmore, Brendan F
Format: Article
Language:English
Subjects:
Alcohol Oxidoreductases - chemistry
Alcohol Oxidoreductases - genetics
Alcohol Oxidoreductases - metabolism
Amines
Amines - metabolism
Biocatalysis
Carbonyls
Cascades
Chemical synthesis
Drug Industry
Enzymes
Monoamine Oxidase - chemistry
Monoamine Oxidase - genetics
Monoamine Oxidase - metabolism
Pharmaceutical industry
Pharmaceuticals
Protein Engineering
Reductases
Stereoisomerism
Transaminases
Transaminases - chemistry
Transaminases - genetics
Transaminases - metabolism
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Summary:Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential “green alternative” to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.7b00437