Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive

•Injectable and in-situ crosslinkable glycol chitosan-based hydrogels were fabricated via blue-light illumination.•The glycol chitosan hydrogel provides strong tissue adhesiveness and hemostatic ability.•The hydrogel incorporated with antibiotics releases the drug in a controlled manner and possesse...

Full description

Saved in:
Bibliographic Details
Published in:Carbohydrate polymers 2018-02, Vol.181, p.668-674
Main Authors: Lu, Min, Liu, Yi, Huang, Yung-Chi, Huang, Chun-Jen, Tsai, Wei-Bor
Format: Article
Language:English
Subjects:
Antibacterial
Glycol chitosan
Hemostasis
Hydrogel
Photochemical crosslinking
Tissue adhesive
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Injectable and in-situ crosslinkable glycol chitosan-based hydrogels were fabricated via blue-light illumination.•The glycol chitosan hydrogel provides strong tissue adhesiveness and hemostatic ability.•The hydrogel incorporated with antibiotics releases the drug in a controlled manner and possesses antibacterial ability. In this work, an in situ gelling system composed of glycol chitosan (GC) was fabricated and evaluated regarding its tissue-adhesive, anti-bacterial and hemostatic properties. GC conjugated with 3-(4-hydroxyphenyl) propionic acid gelled immediately after illumination with blue light in the presence of ruthenium complex. The phenolic GC hydrogel was investigated regarding its mechanical property, hydration, degradation rate, cytotoxicity, tissue adhesiveness, and hemostatic ability. The hydrogel was shown to glue two pieces of tissues tightly in an egg-membrane model. The antibiotic-incorporated hydrogel killed bacteria effectively. When the hydrogel was applied to a wound in a mouse liver model, bleeding was reduced quickly and greatly. All the promising results show that the photo-chemically crosslinkable GC hydrogel could be used as a tissue adhesive, controlled drug release, and a hemostat.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2017.11.097