Staphylococcus aureus, master manipulator of the human hemostatic system

Summary The coagulation system does not only offer protection against bleeding, but also aids in our defense against invading microorganisms. The hemostatic system and innate immunity are strongly entangled, which explains why so many infections are complicated by either bleeding or thrombosis. Stap...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2018-03, Vol.16 (3), p.441-454
Main Authors: Liesenborghs, L., Verhamme, P., Vanassche, T.
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - metabolism
Bleeding
Blood Coagulation
Blood Platelets - metabolism
Coagulase - metabolism
Coagulation
Drug Resistance, Bacterial
Endocarditis
Fibrin
Fibrin - chemistry
Fibrinolysis
Fibronectin
Fibronectins - chemistry
Gram-positive bacteria
Hemostasis
Hemostatics
Humans
Immune System
infective endocarditis
Innate immunity
Medical innovations
Metalloendopeptidases - metabolism
Mice
Penicillin
Plasminogen - chemistry
Platelet Activation
Protein Binding
Protein Domains
Prothrombin
Sepsis
staphylocoagulase
Staphylococcal Infections - blood
Staphylococcus aureus
Staphylococcus aureus - enzymology
Staphylococcus aureus - pathogenicity
Staphylococcus infections
Staphylokinase
Thrombosis
Von Willebrand factor
von Willebrand Factor - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The coagulation system does not only offer protection against bleeding, but also aids in our defense against invading microorganisms. The hemostatic system and innate immunity are strongly entangled, which explains why so many infections are complicated by either bleeding or thrombosis. Staphylococcus aureus (S. aureus), currently the most deadly infectious agent in the developed world, causes devastating intravascular infections such as sepsis and infective endocarditis. During these infections S. aureus comes in close contact with the host hemostatic system and proves to be a master in manipulating coagulation. The coagulases of S. aureus directly induce coagulation by activating prothrombin. S. aureus also manipulates fibrinolysis by triggering plasminogen activation via staphylokinase. Furthermore, S. aureus binds and activates platelets and interacts with key coagulation proteins such as fibrin(ogen), fibronectin and von Willebrand factor. By manipulating the coagulation system S. aureus gains a significant advantage over the host defense mechanisms. Studying the interplay between S. aureus and the hemostatic system can therefore lead to new innovative therapies for battling S. aureus infections.
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.13928