Cerebral amyloid angiopathy – The modified Boston criteria in clinical practice

Early identification of patients with cerebral amyloid angiopathy (CAA) is relevant considering the increased risk for cerebral hemorrhage. A new set of diagnostic criteria for CAA was recently proposed, which include the presence of superficial siderosis. We aimed to assess the impact of applying t...

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Bibliographic Details
Published in:Journal of the neurological sciences 2018-01, Vol.384, p.55-57
Main Authors: Caetano, André, Ladeira, Filipa, Barbosa, Raquel, Calado, Sofia, Viana-Baptista, Miguel
Format: Article
Language:English
Subjects:
Boston criteria
Cerebral amyloid angiopathy
Hemorrhagic stroke
Microhemorrhages
Superficial siderosis
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Summary:Early identification of patients with cerebral amyloid angiopathy (CAA) is relevant considering the increased risk for cerebral hemorrhage. A new set of diagnostic criteria for CAA was recently proposed, which include the presence of superficial siderosis. We aimed to assess the impact of applying these criteria regarding use of antithrombotic therapy. Review of consecutive patients admitted to a Neurology Department from 2014 to 2016, with acute parenchymal or subarachnoid hemorrhage and/or atypical transient focal neurological episodes. Patients with a possible or probable CAA according to the original and modified Boston criteria were included. Information was collected regarding presentation, imaging findings and concomitant therapy. Among a total of 1436 admitted patients, 52 with acute hemorrhagic lesions or atypical TFNE were screened: 22 met criteria for CAA; 4 were deemed too young; 21 had other causes for hemorrhagic parenchymal lesions; and 5 had uncertain diagnosis. Using the modified Boston criteria, 8 patients fulfilled criteria for probable CAA and 14 for possible CAA. When we applied the original Boston criteria to the same patients, only 7 fulfilled criteria for probable CAA and 8 for possible CAA. Among the additional patients identified with the modified Boston criteria, 4 were using antithrombotic therapy. The use of the modified Boston criteria allowed for the identification of 7 additional patients, more than half of which were taking antithrombotic therapy. Systematic use of these criteria could have an important impact in clinical practice. Raising awareness on the different presentations of CAA among clinicians is of the utmost importance. •Cerebral amyloid angiopathy patients have an increased risk for hemorrhagic stroke.•Risk-benefit ratio should be carefully assessed regarding anti-thrombotic treatment.•Some patients with CAA only have disseminated superficial siderosis.•Patients with superficial siderosis can be missed using the classical Boston criteria.•The use of the modified Boston criteria could have important clinical implications.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2017.11.021