α-Lipoic acid ameliorated oxidative stress induced by perilla oil, but the combination of these dietary factors was ineffective to cause marked deceases in serum lipid levels in rats

Dietary perilla oil rich in α-linolenic acid and α-lipoic acid lowers the serum lipid level through changes in hepatic fatty acid metabolism. We therefore hypothesized that the combination of these dietary factors may ameliorate lipid metabolism more than the factors individually. Moreover, α-lipoic...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 2017-12, Vol.48, p.49-64
Main Authors: Ide, Takashi, Tanaka, Ai
Format: Article
Language:English
Subjects:
alpha-Linolenic Acid - adverse effects
Animals
Antioxidant system
Antioxidants - administration & dosage
Cholesterol - blood
Corn Oil - administration & dosage
Dietary Fats - administration & dosage
Hepatic fatty oxidation
Hepatic lipogenesis
Lipid Metabolism - drug effects
Liver - drug effects
Liver - metabolism
Male
Malondialdehyde - blood
Oxidative Stress - drug effects
Palm Oil - administration & dosage
Perilla oil
Plant Oils - adverse effects
Rat
Rats
Rats, Sprague-Dawley
Thioctic Acid - administration & dosage
Triglycerides - blood
α-Linolenic acid
α-Lipoic acid
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Summary:Dietary perilla oil rich in α-linolenic acid and α-lipoic acid lowers the serum lipid level through changes in hepatic fatty acid metabolism. We therefore hypothesized that the combination of these dietary factors may ameliorate lipid metabolism more than the factors individually. Moreover, α-lipoic acid exerts strong anti-oxidative activity. Hence, we also hypothesized that α-lipoic acid may attenuate perilla oil-mediated oxidative stress. We therefore studied the combined effects of perilla oil and α-lipoic acid on lipid metabolism and parameters of oxidative stress. Male rats were fed diets supplemented with 0 or 2.0 g/kg R-α-lipoic acid and containing 120 g/kg of palm (saturated fat), corn (linoleic acid), or perilla oil (α-linolenic acid) for 23 days. Perilla oil compared with other fats decreased serum lipid concentrations in rats fed α-lipoic acid–free diets; however, the combination of perilla oil with α-lipoic acid was ineffective for observing more marked decreases in serum lipid levels. Alterations in hepatic fatty acid synthesis and oxidation may account for the observed changes. Perilla oil, compared with palm and corn oils, strongly increased the malondialdehyde level in the serum and liver. α-Lipoic acid counteracted the increases in these parameters even though the effects were attenuated in the liver. α-Lipoic acid increased the parameters of the anti-oxidant system. The results suggested that α-lipoic acid can ameliorate oxidative stress induced by perilla oil, but the combination of these dietary factors was ineffective for additionally reducing serum lipid levels.
ISSN:0271-5317
1879-0739
DOI:10.1016/j.nutres.2017.10.009