Effectiveness of topical gel of medical leech (Hirudo medicinalis) saliva extract on patients with knee osteoarthritis: A randomized clinical trial

Leech saliva extract (LSE) in the liposome-based gel was used as a supplementary treatment to relief the signs and symptoms of osteoarthritis (OA). The saliva of medical leech was extracted and nano liposomes were used to formulate the supplement to enhance skin absorption. A clinical trial was desi...

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Bibliographic Details
Published in:Complementary therapies in clinical practice 2018-05, Vol.31, p.352-359
Main Authors: Shakouri, Amir, Adljouy, Nasim, Balkani, Sanaz, Mohamadi, Maryam, Hamishehkar, Hamed, Abdolalizadeh, Jalal, Kazem Shakouri, Seyed
Format: Article
Language:English
Subjects:
Absorption
Animals
Arthritis
Body fluids
Clinical research
Clinical trials
Effectiveness
Efficacy
Evidence-based medicine
Hirudo
Inflammation
Knee
Knee osteoarthritis
Leech saliva extract
Liposome
Nursing
Osteoarthritis
Pain
Patients
Quality of life
Questionnaires
Saliva
Self care
Treatment methods
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Summary:Leech saliva extract (LSE) in the liposome-based gel was used as a supplementary treatment to relief the signs and symptoms of osteoarthritis (OA). The saliva of medical leech was extracted and nano liposomes were used to formulate the supplement to enhance skin absorption. A clinical trial was designed to evaluate the therapeutic effects of LSE liposomal gel. Lenquesne and VAS questionnaires were used as indexes of this supplement therapy efficacy for 30 days. Questionnaires analysis showed that after one-month administration of LSE liposomal gel, patients' pain was relieved approximately up to 50%; also, due to reduction in joint inflammation and stiffness, the range of motion was increased and the patients' quality of life was enhanced (p 
ISSN:1744-3881
1873-6947
DOI:10.1016/j.ctcp.2017.12.001