Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors

Absence of cardiovascular risk factors (CVRFs) is traditionally considered low risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events. This study sought to identify predictors of subclinical atherosclerosis in CVRF-free individuals. Participants from th...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2017-12, Vol.70 (24), p.2979-2991
Main Authors: Fernández-Friera, Leticia, Fuster, Valentín, López-Melgar, Beatriz, Oliva, Belén, García-Ruiz, José M., Mendiguren, José, Bueno, Héctor, Pocock, Stuart, Ibáñez, Borja, Fernández-Ortiz, Antonio, Sanz, Javier
Format: Article
Language:English
Subjects:
Adult
Aorta
Arteriosclerosis
Asymptomatic Diseases
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - diagnosis
Bioindicators
Biomarkers
Biomarkers - blood
Blood pressure
Calcification
Calcification (ectopic)
Cardiology
Cardiovascular diseases
Cholesterol
Cholesterol, LDL - blood
Confidence intervals
Coronary artery
Coronary vessels
Disease Progression
Early Diagnosis
Fasting
Female
Follow-Up Studies
Glucose
Health risk assessment
Health risks
Hemoglobin
Humans
Hypertension
LDL-cholesterol
Low density lipoprotein
Male
Medical imaging
Middle age
Middle Aged
Plaques
Prospective Studies
Regression analysis
Risk analysis
Risk Factors
Smoking
Statistical analysis
Tomography
Tomography, X-Ray Computed
Triglycerides
Ultrasonic imaging
Ultrasonography
Ultrasound
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Description
Summary:Absence of cardiovascular risk factors (CVRFs) is traditionally considered low risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events. This study sought to identify predictors of subclinical atherosclerosis in CVRF-free individuals. Participants from the PESA (Progression of Early Subclinical Atherosclerosis) study (n = 4,184) without conventional CVRFs were evaluated (n = 1,779; 45.0 ± 4.1 years, 50.3% women). CVRF freedom was defined as no current smoking and untreated blood pressure 
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.10.024