Serial 4DCT/4DPET imaging to predict and monitor response for locally-advanced non-small cell lung cancer chemo-radiotherapy

A FDG-PET/CT image feature with optimal prognostic potential for locally-advanced non-small cell lung cancer (LA-NSCLC) patients has yet to be identified, and neither has the optimal time for FDG-PET/CT response assessment; furthermore, nodal features have been largely ignored in the literature. We...

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Bibliographic Details
Published in:	Radiotherapy and oncology 2018-02, Vol.126 (2), p.347-354
Main Authors:	Bissonnette, Jean-Pierre, Yap, Mei Ling, Clarke, Katy, Shessel, Andrea, Higgins, Jane, Vines, Douglass, Atenafu, Eshetu G., Becker, Nathan, Leavens, Claudia, Bezjak, Andrea, Jaffray, David A., Sun, Alexander
Format:	Article
Language:	eng
Subjects:	4DCT 4DPET Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - radiotherapy Carcinoma, Non-Small-Cell Lung - therapy Chemoradiotherapy Four-Dimensional Computed Tomography - methods Humans LA-NSCLC Lung Neoplasms - diagnostic imaging Lung Neoplasms - drug therapy Lung Neoplasms - radiotherapy Lung Neoplasms - therapy Positron Emission Tomography Computed Tomography Prognosis Radiotherapy Planning, Computer-Assisted - methods Response monitoring
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Summary:	A FDG-PET/CT image feature with optimal prognostic potential for locally-advanced non-small cell lung cancer (LA-NSCLC) patients has yet to be identified, and neither has the optimal time for FDG-PET/CT response assessment; furthermore, nodal features have been largely ignored in the literature. We propose to identify image features or imaging time point with maximal prognostic power. Consecutive consenting patients with LA-NSCLC receiving curative intent CRT were enrolled. 4DPET/4DCT scans were acquired 0, 2, 4, and 7 weeks during IMRT treatment. Eleven image features and their rates of change were recorded for each time point and tested for each of the possible outcome 2 years post CRT using the Kaplan–Meier method. 32 consecutive patients were recruited, 27 completing all scans. Restricting analysis to 4DPET/4DCT features and rates of change with p
ISSN:	0167-8140 1879-0887