Organocatalytic C(sp3)–H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]azepines

Organocatalytic C(sp3)–H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]azepines

Carbocation-initiated cascade [1,5]-hydride transfer/cyclization and dimerization reactions were developed to synthesize dihydrodibenzo­[b,e]­azepine and octahydrodipyrroloquinoline derivatives in high yields. These redox-neutral C­(sp3)–H functionalization-involving cascade reactions feature transi...

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Bibliographic Details
Published in:Organic letters 2018-01, Vol.20 (1), p.138-141
Main Authors: Li, Shuai-Shuai, Zhou, Lan, Wang, Liang, Zhao, Huaili, Yu, Liping, Xiao, Jian
Format: Article
Language:eng
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Summary:Carbocation-initiated cascade [1,5]-hydride transfer/cyclization and dimerization reactions were developed to synthesize dihydrodibenzo­[b,e]­azepine and octahydrodipyrroloquinoline derivatives in high yields. These redox-neutral C­(sp3)–H functionalization-involving cascade reactions feature transition-metal-free, high atom- and step-economy, and environmental friendliness with water as the sole byproduct.
ISSN:1523-7060
1523-7052