The right atrium in idiopathic hypereosinophilic syndrome: Insights from the 3D speckle tracking echocardiographic MAGYAR-Path Study

Background Idiopathic hypereosinophilic syndrome is characterized by a persistent eosinophil blood count of >1.5 × 10 9 cells/l and organ damage, independent of the primary and secondary causes of eosinophilia. The purpose of the present study was to assess the three-dimensional speckle tracking...

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Bibliographic Details
Published in:Herz 2019-08, Vol.44 (5), p.405-411
Main Authors: Nemes, A., Marton, I., Domsik, P., Kalapos, A., Pósfai, É., Modok, S., Kormányos, Á., Ambrus, N., Borbényi, Z., Forster, T.
Format: Article
Language:English
Subjects:
Cardiology
Internal Medicine
Medicine
Medicine & Public Health
Original Articles
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Summary:Background Idiopathic hypereosinophilic syndrome is characterized by a persistent eosinophil blood count of >1.5 × 10 9 cells/l and organ damage, independent of the primary and secondary causes of eosinophilia. The purpose of the present study was to assess the three-dimensional speckle tracking echocardiography-derived right atrial volumetric and functional properties between hypereosinophilic syndrome patients and matched controls. Methods A total of 11 patients with idiopathic hypereosinophilic syndrome and 22 age- and gender-matched healthy controls were enrolled in the study. Three-dimensional speckle tracking echocardiography was used for calculation of right atrial volumes, volume-based functional properties, and strain parameters. Results Significantly increased right atrial maximum (68.7 ± 33.1 ml vs. 40.3 ± 12.1 ml, respectively; p  = 0.001) and minimum volumes (48.3 ± 31.0 ml vs. 28.3 ± 9.4 ml, respectively; p  = 0.009), as well as right atrial volume before atrial contraction (58.6 ± 27.3 ml vs. 34.5 ± 11.8 ml, respectively; p  = 0.001), were found in hypereosinophilic syndrome patients compared with controls. Total and passive right atrial stroke volumes proved to be significantly increased in hypereosinophilic syndrome patients. However, global and mean segmental strain parameters did not differ significantly between the groups. Conclusion Increased cyclic right atrial volumes and mild alterations in right atrial functional properties could be demonstrated in idiopathic hypereosinophilic syndrome patients.
ISSN:0340-9937
1615-6692
DOI:10.1007/s00059-017-4652-4